Fledgling prognostic markers in CLL

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Fledgling prognostic markers in CLL by Jan A. Burger Blood Volume 110(12):3820-3821 December 1, 2007 ©2007 by American Society of Hematology

ZAP-70 integrates BCR, CD38, and CXCR4 signaling, allowing ZAP-70+/CD38+ CLL cells to home to a stromal microenvironment where they receive growth and survival signals. ZAP-70 integrates BCR, CD38, and CXCR4 signaling, allowing ZAP-70+/CD38+ CLL cells to home to a stromal microenvironment where they receive growth and survival signals. Ligation of CD38 by its ligand CD31 expressed on stromal and nurselike cells induces ZAP-70 phosphorylation. ZAP-70+ enhances CLL cell migration to SDF-1/CXCL12 secreted by stromal and nurselike cells by increasing CXCR4 chemokine receptor signaling downstream of CXCR4-associated G proteins. Moreover, ZAP-70 enhances the capacity of CLL cells to respond to antigen by recruitment of ZAP-70 and Syk to the cytoplasmatic portion of activated BCR complex (CD79 a/b). Jan A. Burger Blood 2007;110:3820-3821 ©2007 by American Society of Hematology