Figure 4 Expression of coagulation protease receptors in renal cells

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Figure 4 Expression of coagulation protease receptors in renal cells Figure 4 | Expression of coagulation protease receptors in renal cells. Protease activated receptor (PAR) 2 is expressed on all types of human renal cells but is not expressed on murine podocytes, whereas PAR3 expression is predominantly restricted to podocytes. Endothelial protein C receptor (EPCR), which promotes protein C activation and activated protein C signalling, is expressed by glomerular endothelial and tubular epithelial cells. Tissue factor (TF) is expressed by podocytes and mesangial cells in humans, whether it is expressed on these cells in other species remains unproven. In various disease models (for example sepsis and diabetic nephropathy) TF expression is induced, but expression of thrombomodulin and EPCR is impaired. Kerlin, B. A. & Isermann, B. et al. (2015) The emerging role of coagulation proteases in kidney disease Nat. Rev. Nephrol. doi:10.1038/nrneph.2015.177