To Titrate or Not: Optimizing Treatment With Antiepileptic Drugs

Program Goals

Epilepsy Prevalence in the United States

Epilepsy Burden

Epilepsy Treatment

Major Depression is Associated With Uncontrolled Seizures

Adverse Events are Common in Epilepsy Patients Retrospective Observational Study

Seizure Frequency Significant Inverse Predictor of HRQoL Across All Domains

AED Titration

Case #1 23-Year-Old Woman With 3rd Episode of Focal Seizures

After Failing Initial First-Line Therapy

Case #2 25-Year-Old Male Veteran with History of Post-Traumatic Epilepsy

Interactions Between AEDs

AEDs and Psychiatric Adverse Effects

Strategies for Treating Drug-Resistant Epilepsy Partial Onset Seizures

Rapid vs Slow Titration

Eslicarbazepine Titration and Adverse Effects

Strategies for Treating Drug-Resistant Epilepsy: Partial Onset Seizures (cont)

Case #3 70-Year-Old Man With Focal Seizures Secondary to Stroke (1½ Years Ago)

Managing AED Therapy in the Elderly

Pharmacogenomic Considerations in AED Metabolism

Epilepsy in the Elderly

VA Study: Discontinuation Due to AEs At 12 months

Newer AEDs Oxcarbazepine & Eslicarbazepine vs Carbamazepine

Principles in Avoiding Adverse Effects With AED Therapy

Abbreviations

References

References (cont)

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References (cont)