Challenging Statin Intolerance: Back to Basics

Slides:



Advertisements
Similar presentations
© 2006 National Lipid Association Statin Safety: Key Conclusions and Recommendations of the NLA.
Advertisements

Clinical question: When do you get statin induced myopathy?
Anti-Hypercholesterolemic Agents  Biosynthesis and Metabolism of Cholesterol  What is arteriosclerosis? - Link between arteriosclerosis and cholesterol.
Livalo (Pitavastatin)
AA-7-1 René Belder, MD Executive Director Clinical Development and Life Cycle Management Cardiovascular / Metabolics 7asdf.
Statin Induce Myotoxicity
Shirley M. Tsunoda Liver Transplant, Drug Metabolism/PK Research Interests Investigating the genetic and environmental factors that influence variability.
Pharmacogenetics.
Joe Ma Research Interests: Drug Metabolism/PK and Pain Past: Examined and validated methods to evaluate drug-drug interaction/phenotyping studies (e.g.,
Presented by Allergy/Intolerance/Adverse Reaction Concept Model HL7 Patient Care WG Discussion Pan Canadian Individual Care Standards Collaborative Working.
Anti hyperlipidemic drugs (lipid lowering drugs) Department of Pharmacology Faculty of Medicine AIMST UNIVERSITY 5 September 2012.
Drug X S-warfarin Agents that DECREASE metabolism (inhibit or compete for cytochrome P450) are more important than those that increase metabolism.
Statins induced myopathy
1st International Online BioMedical Conference (IOBMC 2015)
Muscle pain with taking statin
Anti-Hypercholesterolemic Agents
The Patient Experience With Systemic Lupus Erythematosus
Statin Myopathy (AHA/ACC/NHLBI)
A clinician's guide to statin drug-drug interactions
Drugs, drugs, and more drugs…
Statin Selection in the Elderly
Optimizing Statin Therapy
An Endocrinology Clinic in Dyslipidemia
Tailoring Statin Therapy in Women
Patient Presentation. Patient Presentation PRIMO Study Incidence of Muscle Adverse Effects.
Pharmacokinetics and Drug Interactions in the new HCV Clinical Management SOC.
Moderate-Intensity Statins for Dyslipidemia: How to Treat Today?
Patient-Centered Care in Cystic Fibrosis
Definitions: Seizure, Epilepsy, Epilepsy Syndrome
Pain Management in the Cirrhotic Patient: The Clinical Challenge
Statins and the Elderly Patient
Statin Selection in Special Patient Populations: A Case Challenge
Understanding Statin Metabolism
Patient Presentation. Dyslipidemia Management Beyond Statins: Will PCSK9 Inhibition Trigger a Revolution?
Beyond Statin Therapy.
Goals. The Truth About Statins: High vs Moderate Dose for Secondary Prevention of CAD.
Statins and New-Onset Diabetes REAL Updates and Clinical Implications
Statin Class in Session
Diabetes Increases Risk of CVD
Assessing the State of Statin Therapy
A Pharmacist's Guide to PCSK9 Inhibitors:
What's New in Dyslipidemia?
Statins and Glucose Metabolism: Are All Agents Alike?
Statin Class in Session
PCP View: ACC/AHA Guidelines: Role of Moderate Intensity Statins
Personalizing Statin Therapy in Patients With HIV
A Journal Club on Lipid Management:
PCSK9 Inhibitors and Cardiovascular Outcomes
Improving Appropriate Access to PCSK9 Inhibitors
Patient Selection, Pharmacoeconomics, and PCSK9 Inhibitors
Statins and HIV:.
Exploring Statin Intolerance
Lipid Clinic Challenge
Clinicians' Corner in Dyslipidemia
Definition of Elderly. Advanced Age and CV Risk: To Start or Not to Start a Statin in Older Patients?
Treatment-Resistant Schizophrenia
Addressing Access to PCSK9 Inhibitors: Tips and Tools for Practicing Clinicians.
Statins, Obesity, and Hyperlipidemia
Glucose Management and Statin Therapy
Approximate Dose Equivalency of Statin LDL-C Efficacy.
Goals. The Truth About Statins: High vs Moderate Dose for Secondary Prevention of CAD.
Statins and Glucose Metabolism: An Endocrinology Perspective
Glucose Management and Statin Therapy
The Clinical Implications of Cytochrome P450 Interactions With Opioids and Strategies for Pain Management  Michael J. Brennan, MD  Journal of Pain and.
PCSK9 Inhibitors and Statin Intolerance
Updates on Dyslipidemia
Statin Selection in Patients With Pre-Diabetes: Case Considerations
Drug clearance by metabolism can also decrease with declining kidney function. Drug clearance by metabolism can also decrease with declining kidney function.
PCSK9 Inhibitors and Real-World Evidence
Shared-Decision Making in Dyslipidemia
Presentation transcript:

Challenging Statin Intolerance: Back to Basics

NLA on Statin Intolerance

Ask Yourself: What Is the Cause?

Spectrum of Statin-Associated Muscle Adverse Events

Incidence/Prevalence of Statin Intolerance

Rethinking Statins

Not All Statins Are Created Equal

Statins: High/Medium/Low

CYP450

Statin Pharmacokinetics

Pitavastatin and Pravastatin: Minimal CYP Involvement

Drugs That Interfere With Statin Medications

Human Cytochrome P450 Isoenzymes Known to Oxidize Clinically Used Drugs

Metabolizing Enzymes and Transporters Involved in Statin Drug-Drug Interactions

Gemfibrozil With Statin Drug-Drug Interactions

NLA Recommendations What Should Providers Do?

Let the Patient Tell You About Their Symptoms

NLA Recommendations: Consistent With Those Found in the ACC's Tool

Myth Busters

2015 ACC Health Policy Statement Team Management

Abbreviations