The Role of MRD in Hematologic Malignancies

Educational Objectives

Minimal Residual Disease

Flow Cytometry

MRD Sensitivity Using Flow Cytometry By Disease State

Genetic Methods for MRD Quantification

Allele-Specific Oligonucleotide (ASO)-PCR

MRD Methods – Next Generation Sequencing

MRD Methods – Next Generation Sequencing

ASO-PCR vs NGS

Comparison of MRD Assessment Approaches

Current Role of MRD Assessment in Clinical Care

MRD in Acute Lymphoblastic Leukemia Children’s Oncology Group AALL0232

COG AALL0232: Outcomes

ALL: Outcomes by Quantitative MRD Ranges

MRD Following HCT in ALL

Post Transplant MRD in CLL

MRD and Outcomes in MM

MRD in Non-Hodgkin Lymphoma

Summary of MRD in Lymphoid Malignancies

Future Perspectives in MRD

Abbreviations

References

References (cont)

References (cont)