Epidemiology 1. Update of Anderson et al, J Clin Onc 2010.

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Presentation transcript:

Epidemiology 1. Update of Anderson et al, J Clin Onc 2010

Epidemiology 2. Update of Anderson et al, J Clin Onc 2010

DES and BPA BPA synthesized 19th Century, tested 1935, EC Dodds DES synthesized 1938 by Dodd’s group

Low Concentrations have Big Effects, e.g. Sidenafil 100 mg dose Mol Wt 666.7 25 mg effective for 60% of men

Random Peri-areolar Fine Needle Aspiration

Spherical Growth of HRBECs High-Risk donor Breast Epithelial Cells Matrigel Basal alpha-6 integrin - BLUE Nuclei - Red ER-alpha and ER-beta

Mammalian Target of Rapamycin

mTOR Proteins

Research Plan

Help from the Counterargument Canned Foods At Meals N=20 BPA not in all Teeguarden et al Toxicological Science, 2011