Avanafil for the Treatment of Erectile Dysfunction: A Multicenter, Randomized, Double- Blind Study in Men With Diabetes Mellitus  Irwin Goldstein, MD, LeRoy A. Jones, MD, Laurence H. Belkoff, DO, Gary S. Karlin, MD, Charles H. Bowden, MD, Craig A. Peterson, MS, Brenda A. Trask, BS, Wesley W. Day, PhD  Mayo Clinic Proceedings  Volume 87, Issue 9, Pages 843-852 (September 2012) DOI: 10.1016/j.mayocp.2012.06.016 Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 1 Patient disposition in the study. In total, 1378 patients were enrolled in the study and 390 were assigned randomly to treatment. Of the 390 randomized patients, 333 completed the study and 57 discontinued participation. tx = treatment. Mayo Clinic Proceedings 2012 87, 843-852DOI: (10.1016/j.mayocp.2012.06.016) Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 2 Effect of treatment between baseline and the treatment period on Sexual Encounter Profile (SEP) 3 (intent-to-treat [ITT] population) (A) and SEP 2 (ITT population) (B) and from baseline to the end of treatment on International Index of Erectile Function erectile function (IIEF-EF) domain score (ITT population) (C), normalization of IIEF-EF domain score (≥26) (ITT population) (D), and percentage of successful sexual attempts (SEP 3) over time after dosing (ITT last observation carried forward population) (E). *P<.001 vs baseline; †P=.009 vs baseline; ‡P=.007 vs baseline. Mayo Clinic Proceedings 2012 87, 843-852DOI: (10.1016/j.mayocp.2012.06.016) Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions