Volume 137, Issue 3, Pages e1 (September 2009)

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Volume 137, Issue 3, Pages 873-884.e1 (September 2009) Decline in Male Sexual Desire, Function, and Satisfaction During and After Antiviral Therapy for Chronic Hepatitis C Lorna M. Dove, Raymond C. Rosen, Darmendra Ramcharran, Abdus S. Wahed, Steven H. Belle, Robert S. Brown, Jay H. Hoofnagle Gastroenterology Volume 137, Issue 3, Pages 873-884.e1 (September 2009) DOI: 10.1053/j.gastro.2009.05.060 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 Pretreatment sexual desire, function, and satisfaction by race. (A) Impairment in sexual desire. (B) Erectile dysfunction. (C) Ejaculatory dysfunction. (D) Global dissatisfaction with sex life. Gastroenterology 2009 137, 873-884.e1DOI: (10.1053/j.gastro.2009.05.060) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 Estimated percentage of no, mild, moderate, or severe impairment in the 5 components of sexual health before, during, and after peginterferon and ribavirin therapy. Results of questionnaires administered before therapy (time 0), at 4, 12, and 24 weeks in all patients, and at 48 weeks in virological responders. During follow-up, questionnaires were administered 24 weeks after stopping treatment, which was at week 48 for 6-month virological nonresponders (NR) and week 72 for virological responders (R). (A) Impairment in sexual desire. (B) Erectile dysfunction. (C) Ejaculatory dysfunction. (D) Global satisfaction with sex life. (E) Change in sex life (better, the same, or worse). Gastroenterology 2009 137, 873-884.e1DOI: (10.1053/j.gastro.2009.05.060) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 Impairment in sexual health during and after therapy. The solid line at 1 indicates the reference comparison (the pretreatment assessment). A proportional odds ratio and a 95% CI exceeding and not including 1 indicates significant impairment in the sexual health component compared with baseline. ^Posttreatment follow-up assessment. (A) Among participants undergoing 48 weeks of therapy. (B) Among participants undergoing only 24 weeks of therapy. Gastroenterology 2009 137, 873-884.e1DOI: (10.1053/j.gastro.2009.05.060) Copyright © 2009 AGA Institute Terms and Conditions