Efficacy and Safety of Gabapentin for Uremic Pruritus and Restless Legs Syndrome in Conservatively Managed Patients With Chronic Kidney Disease  Hicham I. Cheikh Hassan, MBBS, Frank Brennan, MBBS, Gemma Collett, BHSc, Elizabeth A. Josland, RN, DipNursing(NZ), MPH, Mark A. Brown, MBBS, MD  Journal of Pain and Symptom Management  Volume 49, Issue 4, Pages 782-789 (April 2015) DOI: 10.1016/j.jpainsymman.2014.08.010 Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 1 Flowchart showing patient selection. RLS = restless legs syndrome. Journal of Pain and Symptom Management 2015 49, 782-789DOI: (10.1016/j.jpainsymman.2014.08.010) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 2 POS-S pruritus symptom score change after gabapentin administration after Visit 1 for patients with pruritus. Time is the interval between the initial consultation (Visit 1) and subsequent visits in weeks (IQR). Total symptom POS-S expressed as mean (SD) for the whole group. Pruritus score between Visit 1 and subsequent visits compared using Wilcoxon signed rank test. We did not censor patients who discontinued gabapentin. IQR = interquartile range; POS-S = Palliative care Outcome Scale-Symptoms. Journal of Pain and Symptom Management 2015 49, 782-789DOI: (10.1016/j.jpainsymman.2014.08.010) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 3 POS-S RLS symptom score change after gabapentin administration after Visit 1, for patients with RLS. Time is the interval between the initial consultation (Visit 1) and subsequent visits in weeks (interquartile range). Total POS score expressed as mean (SD) for the whole group. RLS scores between Visit 1 and subsequent visits compared using Wilcoxon signed rank test. We did not censor patients who discontinued gabapentin. POS-S = Palliative care Outcome Scale-Symptoms; RLS = restless legs syndrome; IQR = interquartile range. Journal of Pain and Symptom Management 2015 49, 782-789DOI: (10.1016/j.jpainsymman.2014.08.010) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions