Identification of a Major Susceptibility Locus for Restless Legs Syndrome on Chromosome 12q Alex Desautels, Gustavo Turecki, Jacques Montplaisir, Adolfo.

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Identification of a Major Susceptibility Locus for Restless Legs Syndrome on Chromosome 12q Alex Desautels, Gustavo Turecki, Jacques Montplaisir, Adolfo Sequeira, Andrei Verner, Guy A. Rouleau The American Journal of Human Genetics Volume 69, Issue 6, Pages 1266-1270 (December 2001) DOI: 10.1086/324649 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 1 Maximum two-point LOD scores, plotted against genetic distance along chromosomes containing regions that provided two-point LOD scores >1.0. “AD” denotes that an autosomal dominant model was used; “AR” denotes that an autosomal recessive model was used. The American Journal of Human Genetics 2001 69, 1266-1270DOI: (10.1086/324649) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 2 Pedigree drawing of the family analyzed, showing haplotypes for six markers located on chromosome 12q. The marker order, from centromere to telomere, is given to the left of each generation. Inferred haplotypes are bracketed. Individuals whose DNA sample was genotyped are indicated by asterisks (*), and unblackened symbols containing a cross (+) denote subjects of unknown disease status (e.g., II:2 and II:6). Double daggers (‡) indicate subjects who are probably affected (II:5 and II:10) but who were not clinically assessed (they were considered as having unknown phenotypes for the linkage analyses). A question mark (?) denotes unknown alleles. The haplotype segregating with the RLS phenotype is boxed. The American Journal of Human Genetics 2001 69, 1266-1270DOI: (10.1086/324649) Copyright © 2001 The American Society of Human Genetics Terms and Conditions