Diversity of Polyubiquitin Chains

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Diversity of Polyubiquitin Chains Anirban Adhikari, Zhijian J. Chen Developmental Cell Volume 16, Issue 4, Pages 485-486 (April 2009) DOI: 10.1016/j.devcel.2009.04.001 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Ubiquitination and Proteasomal Degradation of Ubiquitinated Substrates (A) Schematic illustration of the ubiquitination cascade of a substrate and its subsequent degradation by the 26S proteasome. (B) Structure of ubiquitin (PDB code: 1UBQ) showing seven lysine residues of ubiquitin and the functional consequence of different types of lysine linkages in polyubiquitin chains. (C) Role of K11 polyubiquitination in endoplasmic reticulum-associated degradation (ERAD). Misfolded proteins in the ER are ubiquitinated by membrane-bound E2 and E3 enzymes through K11 of ubiquitin. The ubiquitinated proteins are extracted to the cytosol and then degraded by the 26S proteasome. Developmental Cell 2009 16, 485-486DOI: (10.1016/j.devcel.2009.04.001) Copyright © 2009 Elsevier Inc. Terms and Conditions