A 4 Band intensity (relative unit) 3 2 1 MMP-9 MMP-2 B C 4 4

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A 4 Band intensity (relative unit) 3 2 1 MMP-9 MMP-2 B C 4 4 MMP-9 activity (relative unit) MMP-9 activity (relative unit) 3 3 2 2 1 1 HMGB1 (nM) 0 4 4 HMGB1 (nM) 0 4 4 4 sRAGE (nM) 0 0 30 rTMD123 (nM) 0 0 100 200 SUPPLEMENTARY FIGURE 2. rTMD123 attenuates HMGB1-induced MMP-9 in differentiated THP-1 cells. A, activities of MMP-9 and MMP-2 were assessed after HMGB1 treatment for 24 hours (n=4). B, MMP-9 activity was assessed after sRAGE pretreatment for 1 hour and HMGB1 treatment for 24 hours (n=4). C, MMP-9 activity was assessed after rTMD123 pretreatment for 1 hour and HMGB1 treatment for 24 hours (n=4). (All activities were assessed by gelatin zymography. *P<0.05, **P<0.01, n.s. P>0.05 compared with untreated group. #P<0.05 compared with HMGB1-treated group.)