Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans  Rakesh Pandey, Shipra Gupta, Sudeep Tandon, Olaf Wolkenhauer, Julio Vera, Shailendra K. Gupta  Seizure - European Journal of Epilepsy  Volume 19, Issue 7, Pages 439-442 (September 2010) DOI: 10.1016/j.seizure.2010.06.005 Copyright © 2010 British Epilepsy Association Terms and Conditions

Fig. 1 Structure of Baccoside A, a triterpenoid saponin from Bacopa monnieri Seizure - European Journal of Epilepsy 2010 19, 439-442DOI: (10.1016/j.seizure.2010.06.005) Copyright © 2010 British Epilepsy Association Terms and Conditions

Fig. 2 Observations of seizures/convulsions in C. elegans. (A) Effect of temperature on the swimming behavior. (B and C) Alternating dorsal and ventral body bends pattern in normal swimming and seizure burst. (D) Seizures/convulsions behaviors with repeated unilateral contraction. (E) Continuous convulsions and paralytic body bend patterns. Seizure - European Journal of Epilepsy 2010 19, 439-442DOI: (10.1016/j.seizure.2010.06.005) Copyright © 2010 British Epilepsy Association Terms and Conditions

Fig. 3 Effect of Baccoside A on seizure sensitivity and paralysis of C. elegans at 26–28±1°C. Error bar indicates the standard deviation. Seizure - European Journal of Epilepsy 2010 19, 439-442DOI: (10.1016/j.seizure.2010.06.005) Copyright © 2010 British Epilepsy Association Terms and Conditions

Fig. 4 Effect of Baccoside A on seizure intensity in C. elegans at 26–28±1°C. Error bar indicates the standard deviation. Seizure - European Journal of Epilepsy 2010 19, 439-442DOI: (10.1016/j.seizure.2010.06.005) Copyright © 2010 British Epilepsy Association Terms and Conditions