Airway fibroblasts exhibit a synthetic phenotype in severe asthma

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Presentation transcript:

Airway fibroblasts exhibit a synthetic phenotype in severe asthma Christina C. Lewis, PhD, Hong Wei Chu, MD, Jay Y. Westcott, PhD, Alan Tucker, PhD, Esther L. Langmack, MD, E. Rand Sutherland, MD, Monica Kraft, MD Journal of Allergy and Clinical Immunology Volume 115, Issue 3, Pages 534-540 (March 2005) DOI: 10.1016/j.jaci.2004.11.051 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Baseline procollagen I expression from airway fibroblasts from the three study groups: normal controls (closed dots), mild/moderate asthma (closed squares), and severe asthma (closed triangles). P < .07 when 3 groups compared. Bars denote means. Journal of Allergy and Clinical Immunology 2005 115, 534-540DOI: (10.1016/j.jaci.2004.11.051) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Fibroblast procollagen type I expression after exposure to PDGF isoforms AA (A), BB (B), and AB (C) and IGF-1 (A-C) in normal controls (closed dots), patients with mild/moderate asthma (closed squares), and severe asthma (closed triangles) expressed as percentage of negative, unstimulated control as means ± SEs. ∗P < .05. Journal of Allergy and Clinical Immunology 2005 115, 534-540DOI: (10.1016/j.jaci.2004.11.051) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Fibroblast baseline PDGFR expression. Receptor protein levels are expressed in nanograms per 100 μg total protein. Data from normal healthy control subjects are illustrated with open bars, patients with mild/moderate asthma with filled bars, and patients with severe asthma with shaded bars. ∗P < .05. Journal of Allergy and Clinical Immunology 2005 115, 534-540DOI: (10.1016/j.jaci.2004.11.051) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions