The Hyperresponsiveness of Cells Expressing Truncated Erythropoietin Receptors Is Contingent on Insulin-Like Growth Factor-1 in Fetal Calf Serum by Jacqueline.

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Presentation transcript:

The Hyperresponsiveness of Cells Expressing Truncated Erythropoietin Receptors Is Contingent on Insulin-Like Growth Factor-1 in Fetal Calf Serum by Jacqueline E. Damen, Jana Krosl, Donna Morrison, Steven Pelech, and Gerald Krystal Blood Volume 92(2):425-433 July 15, 1998 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

IGF-1 is a major mitogen in FCS for Ba/F3-d392 cells. IGF-1 is a major mitogen in FCS for Ba/F3-d392 cells. Short-term proliferation assays were performed with Ba/F3-d392 cells stimulated with 100 mU/mL Epo ± 0.2 nmol/L IGF-1, ± 0.2 nmol/L IGF-1 after pretreatment with anti–IGF-1, ± 0.2 nmol/L IGF-1 after pretreatment with control anti-IgG, ± 1% FCS, ± 1% FCS after pretreatment with anti–IGF-1, and ± 1% FCS after pretreatment with control anti-IgG, as described in Materials and Methods. Data points represent the mean ± SE of triplicate determinations. Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology

IGF-1 stimulates the proliferation of Ba/F3, but not DA-3 cells. IGF-1 stimulates the proliferation of Ba/F3, but not DA-3 cells. Short-term IGF-1 dose response studies were performed with three individually isolated Ba/F3 cell clones (parental, ▪; Ba/F3-WT 1, •; Ba/F3 WT 8, ▾) and three individually isolated DA-3 cell clones (DA-3-WT 3, □; DA-3 WT 6, ○; and DA-3-WT 17, ▵) in SS. Data points represent the mean ± SE of triplicate determinations. Jacqueline E. Damen et al. Blood 1998;92:425-433 ©1998 by American Society of Hematology