Christine A. Sorkness, PharmD

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Presentation transcript:

Establishing a therapeutic index for the inhaled corticosteroids: Part II Christine A. Sorkness, PharmD Journal of Allergy and Clinical Immunology Volume 102, Issue 4, Pages S52-S64 (October 1998) DOI: 10.1016/S0091-6749(98)70005-3 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Mechanisms of linear growth inhibition by GCs. Growth-suppressing influences of exogenous GCs on pulsatile GH secretion, IGF-1 bioactivity, GH-receptor expression, collagen synthesis, and adrenal androgen production (proposed) are depicted. GH , Growth hormone (pituitary), IGF-1 , insulin-like growth factor-1; GHRH , growth hormone releasing hormone (pituitary). Reproduced with permission from Allen DB. The influence of inhaled corticosteroids on growth: a pediatric endocrinologist’s perspective. Acta Paediatr 1997;86:1-7. Journal of Allergy and Clinical Immunology 1998 102, S52-S64DOI: (10.1016/S0091-6749(98)70005-3) Copyright © 1998 Mosby, Inc. Terms and Conditions