Cardiac output can be measured with the transpulmonary thermodilution method in a paediatric animal model with a left-to-right shunt A. Nusmeier, W.P.

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Presentation transcript:

Cardiac output can be measured with the transpulmonary thermodilution method in a paediatric animal model with a left-to-right shunt A. Nusmeier, W.P. de Boode, J.C.W. Hopman, P.H. Schoof, J.G. van der Hoeven, J. Lemson British Journal of Anaesthesia Volume 107, Issue 3, Pages 336-343 (September 2011) DOI: 10.1093/bja/aer127 Copyright © 2011 The Author(s) Terms and Conditions

Fig 1 Protocol of the three phases of the experiment. CO is measured alternately during open (unshaded arrow) and closed shunt (solid broad arrow). British Journal of Anaesthesia 2011 107, 336-343DOI: (10.1093/bja/aer127) Copyright © 2011 The Author(s) Terms and Conditions

Fig 2 Transpulmonary thermodilution curves of lamb 1 with a closed and open shunt during stable haemodynamics. British Journal of Anaesthesia 2011 107, 336-343DOI: (10.1093/bja/aer127) Copyright © 2011 The Author(s) Terms and Conditions

Fig 3 The percentage change in the shunt (Qp/Qs) ratio compared with the percentage change in mean transit time (MTt; solid circle) and down slope time (DSt; open square) with an open and closed shunt. The linear correlation is r=0.95 (P<0.001) for the MTt and r=0.96 (P<0.0001) for the DSt. The inverse correlation between the percentage change of Qp/Qs and CO (open triangle) is r=−0.84 (P<0.0001). British Journal of Anaesthesia 2011 107, 336-343DOI: (10.1093/bja/aer127) Copyright © 2011 The Author(s) Terms and Conditions

Fig 4 Bland–Altman plots with closed (a) and open shunt (b). COTPTD and COMPA are the measurements of CO by the TPTD method and perivascular flow probe around the main pulmonary artery, respectively. British Journal of Anaesthesia 2011 107, 336-343DOI: (10.1093/bja/aer127) Copyright © 2011 The Author(s) Terms and Conditions

Fig 5 Correlation between changes in TPTD CO and changes in COMPA (perivascular flow probe around the main pulmonary artery) for the whole experiment with sequential open and closed shunt. British Journal of Anaesthesia 2011 107, 336-343DOI: (10.1093/bja/aer127) Copyright © 2011 The Author(s) Terms and Conditions