by Taizo Wada, Shepherd H. Schurman, G

Slides:



Advertisements
Similar presentations
A. a). d). c). f). b).e). g). Figure S1. NAT2 expression in lymphocytes and monocytes from a healthy volunteer. PBMC from a healthy volunteer were simple.
Advertisements

Validation of a flow cytometric scoring system as a prognostic indicator for posttransplantation outcome in patients with myelodysplastic syndrome by Bart.
Retrovirally Transduced CD34++ Human Cord Blood Cells Generate T Cells Expressing High Levels of the Retroviral Encoded Green Fluorescent Protein Marker.
Flow cytometry-based diagnosis of primary immunodeficiency diseases
Expression of KIR2DL1 on the entire NK cell population: a possible novel immunodeficiency syndrome by Roi Gazit, Ben-Zion Garty, Yehudith Monselise, Vered.
Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation by Ming-Tseh Lin, Li-Hui Tseng, Haydar Frangoul,
Regulation of monocyte procoagulant activity in acute myocardial infarction: role of tissue factor and tissue factor pathway inhibitor-1 by Ilka Ott, Martin.
IFNα-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity.
IFN-γ and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells by Joseph Barbi, Steve Oghumu, Claudio.
The Expression of Bcl-x Is Downregulated During Differentiation of Human Hematopoietic Progenitor Cells Along the Granulocyte But Not the Monocyte/Macrophage.
by Laurence J. N. Cooper, Kevin M. Shannon, Michael R
Genetic Pedigrees.
Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival by Kai-Da Wu, Lisa.
Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator by Esther P.M. Tjin, Patrick W.B.
Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency.
Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation by Yinzhu.
CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood by Mohamed F. Elshal,
Further Analysis of Interleukin-2 Receptor Subunit Expression on the Different Human Peripheral Blood Mononuclear Cell Subsets by Denis David, Lynda Bani,
Lytic Replication of Epstein-Barr Virus in the Peripheral Blood: Analysis of Viral Gene Expression in B Lymphocytes During Infectious Mononucleosis and.
Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9 by Miguel Angel de la Fuente, Victoria.
How I treat elderly patients with myeloma
by Kumudha Balakrishnan, William G. Wierda, Michael J
Tumor cell agglutination and not solely cytokine release as mechanism of adverse reactions during anti-CD20 monoclonal antibody (IDEC-C2B8, rituximab)
Normal prion protein trafficking in cultured human erythroblasts
by Romina Gamberale, Jorge R. Geffner, Julieta Sanjurjo, Paula X
Impaired function of human T-lymphotropic virus type 1 (HTLV-1)–specific CD8+ T cells in HTLV-1–associated neurologic disease by Amir H. Sabouri, Koichiro.
Serum Levels of Substance P Are Elevated in Patients With Sickle Cell Disease and Increase Further During Vaso-Occlusive Crisis by Lisa A. Michaels, Kwaku.
Long-term expansion of effector/memory Vδ2− γδ T cells is a specific blood signature of CMV infection by Vincent Pitard, David Roumanes, Xavier Lafarge,
Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion by Yenan T. Bryceson, Michael E. March, Hans-Gustaf.
Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome by Alexander.
Nonhemolytic antigen loss from red blood cells requires cooperative binding of multiple antibodies recognizing different epitopes by James C. Zimring,
by Wolfram Springer, Alexander von Ruecker, and Roswitha Dickerhoff
T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites by Shigeto Yoshida,
Apoptotic Regulation in Primitive Hematopoietic Precursors
Taking a leaf from the book of oral tolerance
CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection by Rodolfo Silva, Susan Moir,
Incidence, clinical course, and prognosis of secondary monoclonal gammopathy of undetermined significance in patients with multiple myeloma by Rishi K.
by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle
Chronic neutropenia mediated by Fas ligand
by Parisa Asvadi, Zohra Ahmadi, and Beng H. Chong
CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not by Naoko Ishibe, Maher Albitar, Iman.
Apoptotic Vascular Endothelial Cells Become Procoagulant
Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell–depleted stem cell transplantation.
LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis by Albert Gutierrez,
Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia by Phil J. Ancliff, Michael P. Blundell, Giles.
Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets by Maria Nikolova, Jean-Daniel Lelievre, Matthieu.
Cytokine-Release Syndrome in Patients With B-Cell Chronic Lymphocytic Leukemia and High Lymphocyte Counts After Treatment With an Anti-CD20 Monoclonal.
A novel form of complete IL-12/IL-23 receptor β1 deficiency with cell surface-expressed nonfunctional receptors by Claire Fieschi, Marita Bosticardo, Ludovic.
Three generations of patients with lupus erythematosus and hereditary angioedema  Theresa R Pacheco, MD, William L Weston, MD, Patricia C Giclas, PhD,
The Wiskott-Aldrich syndrome
T exosomes bind MAdCAM-1 via RA-increased integrin α4β7.
Abnormal Natural Killer Cell Function in Systemic Sclerosis: Altered Cytokine Production and Defective Killing Activity  Mayuka Horikawa, Minoru Hasegawa,
by Wanqiu Hou, James S. Gibbs, Xiuju Lu, Christopher B
Dysregulation of Lymphocyte Interleukin-12 Receptor Expression in Sézary Syndrome  Mohamed H. Zaki, Ryan B. Shane, Yuemei Geng, Louise C. Showe, Suzanne.
Volume 78, Issue 8, Pages (October 2010)
Phenotype of rTT.C-specific plasma blasts.
Figure 1 BG-12 treatment reduced total circulating B cells and had variable effects on memory B cells BG-12 treatment reduced total circulating B cells.
Actin assembly in response to thrombin.
A and B: Flow cytometric analysis of the effect of MRP-8/14 in the serum of a type 1 diabetic patient on the surface expression of CD11b and CD118. A and.
Erratum in Ledru et al. Alteration of tumor necrosis factor–α T-cell homeostasis following potent antiretroviral therapy: contribution to the development.
More women are affected than men in X-linked Alport syndrome.
X-linked thrombocytopenia identified by flow cytometric demonstration of defective Wiskott-Aldrich syndrome protein in lymphocytes by Hirokazu Kanegane,
by Babs O. Fabriek, Robin van Bruggen, Dong Mei Deng, Antoon J. M
Flow cytometric analysis of T cell activation.
Flow cytometry analysis of intracellular cytokine expression in control PBMC (left set of panels) and following either PMA-ionomycin activation (middle.
Dilution of anti-C6 monoclonal antibody shows the broader linear range of the Multiplex assay in comparison to standard ELISA. Shown is the dilution of.
Patient Tregs express normal levels of suppression.
PD-1 and CD103 are coexpressed on CD8+ T cells but demonstrate distinct mechanisms of regulation. PD-1 and CD103 are coexpressed on CD8+ T cells but demonstrate.
Flow cytometric gating strategy used to identify CD69 surface expression on CD4 (left paired columns) and CD8 (right paired columns) T lymphocytes. Flow.
Hypoxia upregulates CD137 expression in T lymphocytes undergoing activation. Hypoxia upregulates CD137 expression in T lymphocytes undergoing activation.
Presentation transcript:

Multiple patients with revertant mosaicism in a single Wiskott-Aldrich syndrome family by Taizo Wada, Shepherd H. Schurman, G. Jayashree Jagadeesh, Elizabeth K. Garabedian, David L. Nelson, and Fabio Candotti Blood Volume 104(5):1270-1272 September 1, 2004 ©2004 by American Society of Hematology

Family tree and analysis of WASP expression. Family tree and analysis of WASP expression. (A) Simplified pedigree of the study family. Solid squares represent affected men; diagonal lines indicate deceased patients. Carrier status in female patients is indicated by a central dot. (B) Flow cytometric analysis of WASP. PBMCs were fixed, permeabilized, and stained with anti-WASP monoclonal antibody (mAb) (solid histogram) or a control antibody (open histogram), followed by phycoerythrin (PE)–conjugated goat antimouse antibody. Shown are the results of WASP expression in lymphocytes and monocytes from a healthy control and from patients III-1, III-2, III-6, and IV-1. Taizo Wada et al. Blood 2004;104:1270-1272 ©2004 by American Society of Hematology