Diet and asthma: vitamins and methyl donors

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Presentation transcript:

Diet and asthma: vitamins and methyl donors Yueh-Ying Han, PhD, Josh Blatter, MD, John M Brehm, MD, Erick Forno, MD, Augusto A Litonjua, MD, Prof Juan C Celedón, MD The Lancet Respiratory Medicine Volume 1, Issue 10, Pages 813-822 (December 2013) DOI: 10.1016/S2213-2600(13)70126-7 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure Potential mechanisms of action of methyl donors and vitamins (A, C, E, and D) on Th1 and Th2 immune responses BHMT=betaine-homocysteine methyl-transferase. RORγt=retinoic acid-related orphan receptor γt. GATA-3=GATA binding protein 3. T-bet=T-box transcription factor. FOXP3=forkhead box P3. STAT=signal transducer and activator of transcription. TGF=transforming growth factor. MTHFR=methylenetetrahydrofolate reductase. Th=T helper cells. Treg=regulatory T cells. The Lancet Respiratory Medicine 2013 1, 813-822DOI: (10.1016/S2213-2600(13)70126-7) Copyright © 2013 Elsevier Ltd Terms and Conditions