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Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function Kuwabara et al. Am J Nephrol 2017;45:330-337 (DOI:10.1159/000464260) Table 1. Study subjects' demographic data among quartiles of eGFR change

Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function Kuwabara et al. Am J Nephrol 2017;45:330-337 (DOI:10.1159/000464260) Fig. 1. Flow diagram of study enrollment. Of 13,201 subjects who underwent annual medical examination both in 2004 and in 2009, we enrolled 12,578 subjects between 30 and 85 years without chronic kidney disease (eGFR <60 mL/min/1.73 m2) in 2004 in the analyses of this study.

Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function Kuwabara et al. Am J Nephrol 2017;45:330-337 (DOI:10.1159/000464260) Table 2. Risk factors for rapid eGFR decline comparing the highest (4th) quartile with the lowest (1st) quartile of eGFR change

Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function Kuwabara et al. Am J Nephrol 2017;45:330-337 (DOI:10.1159/000464260) Table 3. Odds of rapid eGFR decline for quartile of baseline serum uric acid level and serum uric acid change by gender

Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function Kuwabara et al. Am J Nephrol 2017;45:330-337 (DOI:10.1159/000464260) Fig. 2. The correlations between serum uric acid change and eGFR change over 5 years. There was significant inverse correlations between serum uric acid change and eGFR change for 5 years (r = -0.305, p < 0.001) by Pearson correlation analysis.