Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study R.F. Loeser,

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Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study R.F. Loeser, W. Pathmasiri, S.J. Sumner, S. McRitchie, D. Beavers, P. Saxena, B.J. Nicklas, J. Jordan, A. Guermazi, D.J. Hunter, S.P. Messier Osteoarthritis and Cartilage Volume 24, Issue 8, Pages 1479-1486 (August 2016) DOI: 10.1016/j.joca.2016.03.011 Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Scores plot of OPLS-DA showing separation of progressors (blue circles, right) from non-progressors (green circles, left) at baseline [R2X = 0.2; R2Y = 0.5; Q2 = −0.2]. Osteoarthritis and Cartilage 2016 24, 1479-1486DOI: (10.1016/j.joca.2016.03.011) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Scores plot of OPLS-DA showing separation of progressors (blue circles, right) from non-progressors (green circles, left) at follow up visit after 18 months [R2X = 0.9; R2Y = 1.0; Q2 = −0.5]. Osteoarthritis and Cartilage 2016 24, 1479-1486DOI: (10.1016/j.joca.2016.03.011) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Plot of observed decrease in JSW from baseline to 18 months vs predicted decrease in JSW using OPLS regression of baseline metabolomics data for OA progressors [R2 = 0.94, Q2 = 0.3]. Osteoarthritis and Cartilage 2016 24, 1479-1486DOI: (10.1016/j.joca.2016.03.011) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Plot of observed decrease in JSW from baseline to 18 months vs predicted decrease in JSW using OPLS regression of baseline metabolomics data for OA non-progressors [R2 = 0.96, Q2 = 0.1]. Osteoarthritis and Cartilage 2016 24, 1479-1486DOI: (10.1016/j.joca.2016.03.011) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions