Selecting Therapy for Relapsed/ Refractory Multiple Myeloma

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Presentation transcript:

Selecting Therapy for Relapsed/ Refractory Multiple Myeloma

Case #1

Monitoring Post-ASCT Blood Testing

Other Monitoring After Initial Therapy

Case #1 (cont)

Assessment at Relapse Symptomatic First Relapse

Cytogenetic Testing at Relapse

Therapy Selection Considerations

Recent Phase 3 Trials in R/R MM

ASPIRE Len/Dex ± Carfilzomib

TOURMALINE-MM1 Ixazomib + Len/Dex vs Placebo + Len/Dex

ELOQUENT-2 Len/Dex ± Elotuzumab

POLLUX Len/Dex ± Daratumumab

CASTOR Bor/Dex ± Daratumumab

ENDEAVOR Carfilzomib/Dex vs Bor/Dex

PANORAMA-1 Panobinostat/Bor/Dex vs Placebo/Bor/Dex

Recent Phase 3 Trials in R/R MM

Other Issues to Consider

Special Safety Considerations

Role of Second ASCT in First Relapse

Select Emerging Agents in MM

Key Takeaways

Abbreviations

Abbreviations (cont)

Abbreviations (cont)