Acute hepatitis induced by greater celandine (Chelidonium majus)

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Presentation transcript:

Acute hepatitis induced by greater celandine (Chelidonium majus) Johannes Benninger*, H.Thomas Schneider*, Detlef Schuppan*, Thomas Kirchner‡, Eckhart G. Hahn* Gastroenterology Volume 117, Issue 5, Pages 1234-1237 (November 1999) DOI: 10.1016/S0016-5085(99)70410-5 Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Histology of hepatitis induced by greater celandine. Liver biopsy specimen of patient 1, a 67-year-old woman, 9 months after greater celandine ingestion. (A) Moderate portal and generalized inflammatory infiltrates in the liver (H&E; original magnification 20×). (B) Periportal fibrosis and bridging collapse of reticulin fibers between portal triad and central vein (arrowheads; reticulin silver stain; 20×). (C) Portal and periportal infiltrate of mainly lymphocytes and some granulocytes (H&E; 40×). (D) Intralobular hepatocyte apoptosis (Councilman body) and focal aggregate of Kupffer cells and lymphocytes (H&E; 40×). Gastroenterology 1999 117, 1234-1237DOI: (10.1016/S0016-5085(99)70410-5) Copyright © 1999 American Gastroenterological Association Terms and Conditions