"Base excision DNA repair: from basic science to human disease" DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc. The recent years were marked with identification of some individual repair enzymes, understanding of their structure and many interactions that make base excision repair a functional, versatile system. In this lecture, selected research projects will be presented and implications for human health and disease will be discussed. Dr. Dmitry Zharkov Associate Professor Institute of Chemical Biology and Fundamental Medicine Novosibirsk State University Novosibirsk, Russia Monday, Oct 25, 4 PM. SL120. Refreshments: CB 275 at 3:45 PM