Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in.

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Presentation transcript:

Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms Laure Sarda-Mantel, MD, PhD, Jean-Marc Alsac, MD, Raphaël Boisgard, PhD, Florence Hervatin, PhD, Françoise Montravers, MD, PhD, Bertrand Tavitian, MD, PhD, Jean-Baptiste Michel, MD, PhD, Dominique Le Guludec, MD, PhD Journal of Vascular Surgery Volume 56, Issue 3, Pages 765-773 (September 2012) DOI: 10.1016/j.jvs.2012.01.069 Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 1 A, Positive fluoro-deoxy-glucose (FDG)-positron-emission tomography (PET) in a rat with abdominal aortic aneurysm (AAA). a, FDG-PET imaging in a rat with AAA. Increased FDG uptake (arrows) is seen in AAA parietal wall compared with normal aorta. b, FDG-PET in a sham-operated rat; no increased FDG uptake is observed in normal abdominal aorta. c, Autoradiography of AAA (left) and normal aorta (right); intense FDG uptake is observed in AAA. B, Positive fluoro-methyl-choline (FCH)-PET in a rat with AAA (arrow). a, PET axial view. b, PET frontal view. c, Autoradiography of AAA (left) and normal aorta (right). Activity ratio between AAA and normal aorta sections is 3.1. C, Comparison of FDG and FCH uptakes on PET imaging* and autoradiography. FCH uptake in AAA parietal wall is lower than that of FDG, with lower SUVmax and T/B ratios on PET imaging, as well as lower ANR on autoradiography. ANR, AAA-to-normal thoracic aorta activity ratio on autoradiography; T/B, AAA-to-background SUVmax ratio on PET imaging. *FDG and FCH imaging in the same rats. Journal of Vascular Surgery 2012 56, 765-773DOI: (10.1016/j.jvs.2012.01.069) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 2 Evolution of fluoro-deoxy-glucose (FDG) (left column) and fluoro-methyl-choline (FCH) (right column) uptakes in abdominal aortic aneurysms (AAAs) as function of AAA diameter and time after the graft. Journal of Vascular Surgery 2012 56, 765-773DOI: (10.1016/j.jvs.2012.01.069) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 3 Examples of 18F-DPA714 positron-emission tomography (PET) and autoradiographic data. A, 18F-DPA714 PET frontal view of a rat with inflamed abdominal aortic aneurysm (AAA), 30 to 60 minutes postinjection; similar tracer uptake is observed in AAA and subjacent iliac arteries. B, Ex vivo labeling of AAA (upper panel) and normal aorta (lower panel) in another rat; high 18F-DPA714 uptake is observed in both tissues with comparable intensity (a), which disappears in the presence of unlabeled PK11195 (b) or DPA714 (c), indicating specific labeling of peripheral benzodiazepine receptors in both AAA and normal aorta wall. Journal of Vascular Surgery 2012 56, 765-773DOI: (10.1016/j.jvs.2012.01.069) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 4 Immunohistology of an abdominal aortic aneurysm (AAA). Adventitial CD8 (A) and ED1 (B) stainings in a large AAA. a, Negative control. b, Corresponding stained area. c, Whole AAA section staining. Journal of Vascular Surgery 2012 56, 765-773DOI: (10.1016/j.jvs.2012.01.069) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 5 Relation between positron-emission tomography (PET) images quantification and number of leukocytes on histology. T/B ratio, Ratio of SUVmax in abdominal aortic aneurysm (AAA) to SUVmax in surrounding tissue vs CD8; ED1, number of stained cells per tissue sections. Journal of Vascular Surgery 2012 56, 765-773DOI: (10.1016/j.jvs.2012.01.069) Copyright © 2012 Society for Vascular Surgery Terms and Conditions