Nor Supp.Fig. S1 Raja et al. a b c d e f 1 2 Hyp - + Hyp - +

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Nor + + - - - Supp.Fig. S1 Raja et al. a b c d e f 1 2 Hyp - + Hyp - + 1 2 OPN Hyp - + Time (hr) 0 16 Actin MCF-7 b OPN/ DAPI Hyp - + Time (hr) 0 16 1 2 MCF-7 1 2 3 4 5 HIF1α HIF1β Actin Nor + + - - - Hyp - - + + + Coni - + + - - OPNi - - - + - β3i - - - - + MCF-7 c Actin d β3-Integrin 1 2 3 β3i C Coni OPN 1 2 3 C Coni OPNi MDA-MB-231 e GAPDH (188 bp) OPN (400 bp) WT KO 1 2 MEF 200 bp 400 bp 300 bp Actin HIF1α 1 2 3 MCF-7 Hyp + + + rhOPN - 0.25 0.5 (μM) f Supp.Fig. S1 Raja et al.

Supp.Fig. S2 Raja et al. a b c Akt 1 2 3 p-p65 p65 p-Akt 231 OPNshRNA 1 2 3 p-p65 p65 p-Akt 231 OPNshRNA Nor Hyp MDA-MB-231 b Actin HIF1α 1 2 3 VEGF 231 OPNshRNA Nor Hyp MDA-MB-231 c Actin OPN 1 2 231 OPNshRNA MDA-MB-231 Supp.Fig. S2 Raja et al.

Supp.Fig.S3 Raja et al. a b c * * Nor Hyp Hyp+ Coni Hyp + OPNi T=0 h T=16 h Nor Hyp Hyp+ Coni Hyp + OPNi Hyp + β3 i Hyp +IgG Hyp +OPN Neu Ab MDA-MB-231 a % Wound Closure c MDA-MB-231 T=0 h T=16 h Hypoxia + + + rhOPN (0.25 µM) - + - OPN shRNA - - + b * * Hyp + + + rh OPN - + - (0.25 µM) OPN shRNA - - + Supp.Fig.S3 Raja et al.

Supp.Fig.S4 Raja et al. Nor T=0h T=16h Hyp OPN (0.5μM) - + + + - Coni - - + - - HIF1α i - - - + + T=0h T=16h Nor Hyp MDA-MB-231 Supp.Fig.S4 Raja et al.

Supp.Fig.S5 Raja et al. a c b * ** Coni Coni OPNi β3 i MDA-MB-231 Nor Hyp Migration c Nor Hyp Hyp+ Coni Hyp +OPNi Hyp+ β3 i MDA-MB-231 % Migration Nor + - - - Hyp - + + + Coni + + - - OPNi - - + - β3 i - - - + * ** b Invasion Supp.Fig.S5 Raja et al.

MCF-7 MCF-OPN-a HIF2α DAPI Hyp + + (16 h) Supp.Fig.S6 Raja et al.

Supplementary Table S1 Raja et al. Correlation coefficient of OPN and HIF1α expression in human breast cancer Supplementary Table S1 Raja et al.

** Correlation is significant at 0.01level (2 tailed) Correlation coefficient of OPN, HIF1α and HIF2α expression in human breast cancer Spearman’s rho Correlation Coefficient Sig (2-tailed) HIF1α -OPN 0.613 P=0.005** HIF1α - HIF2α 0.181 P=0.458 OPN- HIF2α 0.337 P=0.158 N=19 ** Correlation is significant at 0.01level (2 tailed) Supplementary Table S2 Raja et al.