Increased Plasma Indoleamine 2,3-Dioxygenase Activity and Interferon-γ Levels Correlate with the Severity of Acute Graft-versus-Host Disease after Allogeneic.

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Increased Plasma Indoleamine 2,3-Dioxygenase Activity and Interferon-γ Levels Correlate with the Severity of Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation Jinhuan Xu, Jia Wei, Xianmin Zhu, Xiaomei Zhang, Jun Guan, Jiaqi Wang, Jin Yin, Yi Xiao, Yicheng Zhang Biology of Blood and Marrow Transplantation Volume 19, Issue 2, Pages 196-201 (February 2013) DOI: 10.1016/j.bbmt.2012.10.013 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 The IDO mRNA expression detected by RT-PCR in peripheral blood mononuclear cells. Lanes 1-2: healthy volunteers, lanes 3-4: patients before infusion of stem cells, lanes 5-7: patients without aGVHD, lanes 8-10: patients with aGVHD. GAPDH was used as a loading control. Biology of Blood and Marrow Transplantation 2013 19, 196-201DOI: (10.1016/j.bbmt.2012.10.013) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Comparison of plasma IDO activity in different groups (A and B). Ctl indicates healthy volunteers; pre-HSCT, blood samples from patients before infusion of stem cells; non-aGVHD, no aGVHD at the first time of sample draw; aGVHD, patients with aGVHD; AU, arbitrary units. Bars indicate the mean values for each group. Statistical analyses: Kruskal-Wallis, analysis of variance, and Mann-Whitney U test. Biology of Blood and Marrow Transplantation 2013 19, 196-201DOI: (10.1016/j.bbmt.2012.10.013) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 The dynamic change of IDO activity in patients with aGVHD. AE, the IDO activity of patients after engraftment and do not present with aGVHD; aGVHD, the IDO activity of patients at the onset of aGVHD; CR, the IDO activity of patients when aGVHD were completely relieved; RE, the IDO activity of patients when aGVHD recurred. Biology of Blood and Marrow Transplantation 2013 19, 196-201DOI: (10.1016/j.bbmt.2012.10.013) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Comparison of the plasma levels of IFN-γ in different groups (A and B) and analysis of the correlation of IDO activity with IFN-γ expression (C). Ctl indicates the healthy volunteers; pre-HSCT, blood samples from patients before infusion of stem cells; non-aGVHD, no aGVHD at the first time of sample draw; aGVHD, patients with aGVHD. Bars indicate the mean values for each group. Statistical analyses: Kruskal-Wallis, analysis of variance, Mann-Whitney U test, and linear regression. Biology of Blood and Marrow Transplantation 2013 19, 196-201DOI: (10.1016/j.bbmt.2012.10.013) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 ROC curve analysis of plasma IDO activity and IFN-γ levels. (A) Area under the ROC curve for IDO activity and IFN-γ levels was .852 (95% CI, .773-.931; P = .000) and .694 (95% CI, .586-.803; P = .003), respectively. (B) A composite ROC curve of both IDO activity and IFN-γ levels; the area under the ROC curve was .849 (95% CI, .770-.929; P = .000). Biology of Blood and Marrow Transplantation 2013 19, 196-201DOI: (10.1016/j.bbmt.2012.10.013) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions