Genetic Variants in Fanconi Anemia Pathway Genes BRCA2 and FANCA Predict Melanoma Survival  Jieyun Yin, Hongliang Liu, Zhensheng Liu, Li-E. Wang, Wei V. Chen, Dakai Zhu, Christopher I. Amos, Shenying Fang, Jeffrey E. Lee, Qingyi Wei  Journal of Investigative Dermatology  Volume 135, Issue 2, Pages 542-550 (February 2015) DOI: 10.1038/jid.2014.416 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Kaplan–Meier survival analysis.For cutaneous melanoma (CM) overall survival (OS; a) by 0, 1, 2, and 3/4 number of unfavorable genotypes (NUG) (i.e., rs10492396 AG, rs206118 CC, rs3752447 CC, and rs62068372 TT) and (b) by 0–1 and 2–4 NUG; for CM MSS (c) by 0, 1, 2, and 3/4 NUG and (d) by 0–1 and 2–4 NUG. Journal of Investigative Dermatology 2015 135, 542-550DOI: (10.1038/jid.2014.416) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Receiver operating characteristic (ROC) curves for prediction of cutaneous melanoma (CM) survival.(a) Five-year overall survival (OS) rate and (b) five-year melanoma-specific survival (MSS) rate, based on tumor stage and thickness, tumor stage, Breslow thickness plus NUG. Journal of Investigative Dermatology 2015 135, 542-550DOI: (10.1038/jid.2014.416) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Upregulation of BRCA2 (a, b) and FANCA (c, d) in the progression of melanoma.The y axis is a score representing the expression levels of BRCA2 and FANCA. Journal of Investigative Dermatology 2015 135, 542-550DOI: (10.1038/jid.2014.416) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Single-nucleotide polymorphism (SNP)–gene expression associations.Analyses of BRCA2 expression levels by genotypes of (a) rs10492396, (b) rs206118, (c) rs3752447, and (d) combined risk genotypes (i.e., rs206118 CC, rs10492396 AG, and rs3752447 CC) in 270 HapMap lymphoblastoid cell lines from all population. The number of individuals with missing data for rs10492396, rs206118, and combined risk genotypes was 2, 2, and 4, respectively. The y axis is the normalized gene expression level. Journal of Investigative Dermatology 2015 135, 542-550DOI: (10.1038/jid.2014.416) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions