Simvastatin attenuates cardiac isograft ischemia-reperfusion injury by down-regulating CC chemokine receptor-2 expression Rong Yin, MD, Jiaquan Zhu,

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Presentation transcript:

Simvastatin attenuates cardiac isograft ischemia-reperfusion injury by down-regulating CC chemokine receptor-2 expression Rong Yin, MD, Jiaquan Zhu, MD, Zhongqiu Wang, MD, Hairong Huang, MD, Jianjun Qian, MD, Zhongdong Li, MD, Hua Jing, MD The Journal of Thoracic and Cardiovascular Surgery Volume 134, Issue 3, Pages 780-788 (September 2007) DOI: 10.1016/j.jtcvs.2007.05.001 Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Representative slices of hearts from the CON and SIM groups at 1 day after transplantation. Slices were stained with 2, 3, 5-triphenyl tetrazolium chloride. The risk but viable area (red) and the infarct area (white-gray). B, Effects of simvastatin on infarct size. Mean ± standard deviation, n = 4 per group. *P < .05 versus control group. IS, Infarct size; AAR, area at risk. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 780-788DOI: (10.1016/j.jtcvs.2007.05.001) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Representative slices of donor hearts from CON and SIM recipients. Simvastatin significantly attenuated cell interstitial fibrosis (A) (Masson, ×200), macrophage (B) (CD68 stain ×400), and neutrophil (C) (HIS4 stain, ×400) infiltration. Effects of simvastatin treatment on interstitial fibrosis (D), macrophage (E), and neutrophil (F) infiltration at different time points. Mean ± standard error of the mean (SEM), n = 6 rats per time point in each group. ##P < .01 between control (open bars) and simvastatin (filled bars) groups, NS, Not significant. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 780-788DOI: (10.1016/j.jtcvs.2007.05.001) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 MPO activity in sham, CON, and SIM groups. MPO activity in the SIM group was significantly decreased at 1 day and 3 days after transplantation compared with the control group. Mean ± SEM, n = 6 rats per time point in each group. *P < .05, ##P < .01 between CON and SIM groups. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 780-788DOI: (10.1016/j.jtcvs.2007.05.001) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Concentration of MCP-1 in serum and isografts. Both MCP-1 levels in serum and grafts were significantly elevated in the CON group compared with the sham group. The serum level of MCP-1 was markedly decreased in the SIM group at each time point compared with the control group (A). The intragraft level of MCP-1 was not only decreased but also delayed in the SIM group compared with the control group (B). Mean ± SEM, n = 6 rats per time point in each group. *P < .05, ##P < .01, **P < .001 between CON and SIM groups. MCP-1, Monocyte chemoattractant protein-1. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 780-788DOI: (10.1016/j.jtcvs.2007.05.001) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Quantitative real-time PCR of CCR2 mRNA expression in cardiac isografts. The expression of CCR2 was significantly up-regulated in the CON group, which was reversed in the SIM group at 1, 3, and 7 days after transplantation. Mean ± SEM, n = 6 rats per time point in each group. *P < .05, ##P < .01 between CON and SIM groups. CCR2, CC chemokine receptor-2. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 780-788DOI: (10.1016/j.jtcvs.2007.05.001) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions