I. The Historical Development of Microbiology A. The Discovery and Significance of Microorganisms B. Vaccines and Antimicrobial Therapy C. Microbes and Industry D. Emergent Diseases and the Post-Antibiotic Era

I. A. Discovery and Significance Discovery of microorganisms 1670s van Leeuwenhoek

I. A. Discovery and Significance Spontaneous Generation vs Biogenesis 1688 Redi 1750 Needham vs Spallanzani 1860s - 70s Pasteur & Tyndall

I. A. Discovery and Significance Microbes and Disease 1790 Jenner 1835 Bassi 1847 Semmelweis 1849 Snow 1867 Lister 1860s - 80s Pasteur 1870s - 80s Koch

I. A. Discovery and Significance Pure Culture Technique 1870s - 80s Koch Streak Plate Method

I. A. Discovery and Significance Microbes and the Environment late 1800s Winogradsky Beijerinck

I. B. Vaccines and Antimicrobial Therapy 1790s Jenner 1860s-70s Pasteur 20th century accomplishments

I. B. Vaccines and Antimicrobial Therapy Pre-antibiotic era Antibiotics

I. C. Microbes and Industry Water and Wastewater Treatment Food Microbiology Recombinant DNA Technology

I. D. Emergent Diseases and the Post-Antibiotic Era “New” Diseases Resurgence of “old” diseases Microbial resistance to drugs Immunosupression Are we in a “post-antibiotic” era?