Therapeutic angiogenesis with intramyocardial administration of basic fibroblast growth factor Michio Kawasuji, MD, Hiroshi Nagamine, MD, Masahiro Ikeda,

Slides:

Advertisements

Similar presentations

Paracrine Action Enhances the Effects of Autologous Mesenchymal Stem Cell Transplantation on Vascular Regeneration in Rat Model of Myocardial Infarction

Advertisements

Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery Manuel Castellá, MD, Gerald D.

B. Zane Atkins, MD, Scott C. Silvestry, MD, Ravi N. Samy, MD, Ashish S

Therapeutic Effect of Midkine on Cardiac Remodeling in Infarcted Rat Hearts Shinya Fukui, MD, Satoru Kitagawa-Sakakida, MD, PhD, Sin Kawamata, MD, PhD,

Epicardial infarct repair with basic fibroblast growth factor–enhanced CorMatrix-ECM biomaterial attenuates postischemic cardiac remodeling Holly E.M.

Therapeutic angiogenesis using autologous bone marrow stromal cells: improved blood flow in a chronic limb ischemia model Abdulaziz Al-Khaldi, MD, Hilal.

A combination of omental flap and growth factor therapy induces arteriogenesis and increases myocardial perfusion in chronic myocardial ischemia: Evolving.

Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure Daniel Zimpfer, MD, Seyedhossein.

Multislice Computed Tomography for Preoperative Evaluation of Right Ventricular Volumes and Function: Comparison With Magnetic Resonance Imaging Alexander.

Cardiomyocyte transplantation does not reverse cardiac remodeling in rats with chronic myocardial infarction Yutaka Sakakibara, MD, Keiichi Tambara,

Volume 75, Issue 1, Pages 7-9 (January 2009)

Repair of Myocardial Infarction by Epicardial Deposition of Bone Marrow Cell-Coated Muscle Patch in a Murine Model Laurent Barandon, MD, Thierry Couffinhal,

Comparative effects of mesenchymal progenitor cells, endothelial progenitor cells, or their combination on myocardial infarct regeneration and cardiac.

A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion.

Hybrid Surgical Angiogenesis: Omentopexy Can Enhance Myocardial Angiogenesis Induced by Cell Therapy Taro Kanamori, MD, Go Watanabe, MD, Tamotsu Yasuda,

Coronary artery bypass grafting on the beating heart evaluated with integrated backscatter Kenichi Imasaka, MD, Shigeki Morita, MD, Ichiro Nagano, MD,

Downregulation of the CXC chemokine receptor 4/stromal cell–derived factor 1 pathway enhances myocardial neovascularization, cardiomyocyte survival, and.

Paracrine Action Enhances the Effects of Autologous Mesenchymal Stem Cell Transplantation on Vascular Regeneration in Rat Model of Myocardial Infarction

Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects Jay G. Shake, MD, Peter J. Gruber, MD, PhD,

Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn.

Takotsubo Cardiomyopathy After Coronary Intervention Developed During Hospitalization Jamal Hussain, MD, Nathan Laufer, MD, Suzane Sorrof, MD, Ashish.

Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF G.Chad Hughes, MD, Shankha S Biswas, MD, Bangliang.

Hiroshi Takami, MD, Taizo Hiraishi, MD, Tohru Kobayashi, MD

Intramyocardial thrombin promotes angiogenesis and improves cardiac function in an experimental rabbit model of acute myocardial infarction Sofoklis.

Ventricular septal rupture caused by myocardial bridging

Biodegradable vs Nonbiodegradable Cardiac Support Device for Treating Ischemic Cardiomyopathy in a Canine Heart Mutsunori Kitahara, MD, Shigeru Miyagawa,

Improved Myocardial Perfusion and Thickening After Off-Pump Revascularization: 5- Year Follow-Up Chang Young Kim, MD, Ho Young Hwang, MD, Jin Chul Paeng,

Biodegradable elastic patch plasty ameliorates left ventricular adverse remodeling after ischemia–reperfusion injury: A preclinical study of a porous.

Pravastatin Improves Remodeling and Cardiac Function After Myocardial Infarction by an Antiinflammatory Mechanism Rather than by the Induction of Angiogenesis

Intramyocardial Left Ventricle-to-Coronary Artery Stent: A Novel Approach for the Treatment of Coronary Artery Disease Geng-Hua Yi, MD, Eva Maria Becker,

Myocardial tactile stiffness during acute reduction of coronary blood flow Kagami Miyaji, MD, Seiryo Sugiura, MD, Hirotaka Inaba, MD, Shinichi Takamoto,

Homing of intravenously infused embryonic stem cell-derived cells to injured hearts after myocardial infarction Jiang-Yong Min, MD, Xuling Huang, MD,

Spinal cord stimulation treatment for angina pectoris: more than a placebo? Philippe A Gersbach, MD, Mustafa G Hasdemir, MD, Eric Eeckhout, MD, PhD, Ludwig.

Therapeutic angiogenesis induced by local autologous bone marrow cell implantation Kimikazu Hamano, MD, Tao-Sheng Li, MD, Toshiro Kobayashi, MD, Ken Hirata,

Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 1211 Leonard Y Lee, MD, Shailen.

Therapeutic Potential of Human Umbilical Cord Derived Stem Cells in a Rat Myocardial Infarction Model Kai Hong Wu, MD, PhD, Bin Zhou, PhD, Cun Tao Yu,

Proteasome Inhibition Attenuates Infarct Size and Preserves Cardiac Function in a Murine Model of Myocardial Ischemia-Reperfusion Injury William E. Stansfield,

Endogenous myocardial angiogenesis and revascularization using a gastric submucosal patch Marc A Ruel, MD, MPh, Frank W Sellke, MD, Cesario Bianchi,

Aortic root replacement with anomalous origin of the coronary arteries

Myocardial revascularization with the posterior tibial artery

Novel regenerative therapy using cell-sheet covered with omentum flap delivers a huge number of cells in a porcine myocardial infarction model Yasuhiro.

Temporal Changes in Infarct Material Properties: An In Vivo Assessment Using Magnetic Resonance Imaging and Finite Element Simulations Jeremy R. McGarvey,

Improved perfusion and contractile reserve after transmyocardial laser revascularization in a model of hibernating myocardium G.Chad Hughes, MD, Alan.

Coronary Artery Fistulae Involving Both Right and Left Coronary Arteries Ahmet Bolukcu, MD, Ahmet Can Topcu, MD, Yavuz Sensoz, MD, Ilyas Kayacioglu, MD

Transposition of the great arteries with anomalous origin of the left coronary artery from the pulmonary artery Masaaki Yamagishi, MD, Takeshi Emmoto,

Complete Revascularization of the Three-Vessel Territories Using a Left Internal Thoracic Artery Composite Graft Ho Young Hwang, MD, PhD, Hong Chul Oh,

Single coronary artery and complete transposition of the great arteries: a technical challenge resolved? Vinayak Shukla, Robert M Freedom, MD, Michael.

Significant improvement of heart function by cotransplantation of human mesenchymal stem cells and fetal cardiomyocytes in postinfarcted pigs Jiang-Yong.

Efficacy of Therapeutic Angiogenesis by Intramyocardial Injection of pCK-VEGF165 in Pigs Jae-Sung Choi, MD, PhD, Ki-Bong Kim, MD, PhD, Woong Han, DVM,

Layered implantation of myoblast sheets attenuates adverse cardiac remodeling of the infarcted heart Naosumi Sekiya, MD, Goro Matsumiya, MD, PhD, Shigeru.

Up-regulation of vascular endothelial growth factor mrna and angiogenesis after transmyocardial laser revascularization Keith A Horvath, MD, Elaine Chiu,

Elimination of Ischemic Mitral Regurgitation Does Not Alter Long-Term Left Ventricular Remodeling in the Ovine Model Kanji Matsuzaki, MD, PhD, Masato.

Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation Yutaka.

Near-infrared monitoring of myocardial oxygenation during ischemic preconditioning Michio Kawasuji, MD, Masahiro Ikeda, MD, Naoki Sakakibara, MD, Susumu.

Angiogenesis and growth factor expression in a model of transmyocardial revascularization Marc P. Pelletier, MD, Adel Giaid, PhD, Sujith Sivaraman, BSc,

Multislice Computed Tomography for Preoperative Evaluation of Right Ventricular Volumes and Function: Comparison With Magnetic Resonance Imaging Alexander.

Comparison of developmental endothelial locus-1 angiogenic factor with vascular endothelial growth factor in a porcine model of cardiac ischemia Murray.

Transmyocardial laser revascularization: experimental studies in healthy porcine myocardium Georg Lutter, MD, Juergen Martin, MD, Noriyuki Takahashi,

Daniel J Goldstein, MD, David Rabkin, MD, Henry M Spotnitz, MD

Intraoperative Electroanatomic Mapping

Myoblast-seeded biodegradable scaffolds to prevent post–myocardial infarction evolution toward heart failure Matthias Siepe, MD, Marie-Noëlle Giraud,

Peter Pecher, MD, Bernd A Schumacher, MD

Staged Therapeutic Approach in Spontaneous Coronary Dissection

Coronary bypass flow during use of intraaortic balloon pumping and left ventricular assist device Takeo Tedoriya, MD, Michio Kawasuji, MD, Naoki Sakakibara,

An experimental model of chronic myocardial hibernation

Skeletal muscle ventricle aortic counterpulsation: function during chronic heart failure Bhavik G Patel, MD, Sachin H Shah, MD, Lou I Astra, MD, Robert.

Andrew D Cochrane, Shobhna Pathik, Joseph J Smolich, Robert A

Anomalous right coronary artery from the pulmonary artery in Taussig-Bing anomaly Benjamin W Eidem, MD, Frank Cetta, MD, Patrick T Roughneen, Serafin.

Therapeutic Angiogenesis With Basic Fibroblast Growth Factor: Technique and Early Results Frank W Sellke, MD, Roger J Laham, MD, Elazer R Edelman, MD,

Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.

Presentation transcript:

Therapeutic angiogenesis with intramyocardial administration of basic fibroblast growth factor Michio Kawasuji, MD, Hiroshi Nagamine, MD, Masahiro Ikeda, MD, Naoki Sakakibara, MD, Hirofumi Takemura, MD, Susumu Fujii, MD, Yoh Watanabe, MD The Annals of Thoracic Surgery Volume 69, Issue 4, Pages 1155-1161 (April 2000) DOI: 10.1016/S0003-4975(99)01557-X

Fig 1 Experimental model used to make myocardial infarction by ligation of the left anterior descending coronary artery (LAD) and provide direct administration of basic fibroblast growth factor or placebo into the myocardium. The left atrial catheter was positioned for administration of colored microspheres. After all blood flow measurements, the heart was cut into short-axis slices and the left ventricle was divided into eight segments. (LCX = left circumflex coronary artery; RCA = right coronary artery.) The Annals of Thoracic Surgery 2000 69, 1155-1161DOI: (10.1016/S0003-4975(99)01557-X)

Fig 2 Heart tissue in the border zone of infarct in a dog treated with basic fibroblast growth factor (bFGF) (A) and a control dog (B). Vessels were expressed by staining endothelial cells using a monoclonal antibody against von Willebrand factor. Increased capillaries and arterioles were noted in an infarct-adjacent region of a bFGF-treated dog. (×200.) The Annals of Thoracic Surgery 2000 69, 1155-1161DOI: (10.1016/S0003-4975(99)01557-X)

Fig 3 Effect of basic fibroblast growth factor (bFGF) on myocardial blood flow, which is shown as percent of normal (%MBF). A marked increase in %MBF is evident in bFGF-treated dogs during the period from 3 to 7 days after infarction. (A) Endocardial portion of the infarcted area. (B) Epicardial portion of the infarcted area. (C) Endocardial portion of the border zone. (D) Epicardial portion of the border zone. (NS = not significant.) The Annals of Thoracic Surgery 2000 69, 1155-1161DOI: (10.1016/S0003-4975(99)01557-X)

Fig 4 Effect of basic fibroblast growth factor (bFGF) on left ventricular function. Treatment with bFGF improved left ventricular ejection fraction 7 days after infarction. (LVEDV = left ventricular end-diastolic volume; LVESV = left ventricular end-systolic volume; NS = not significant.) The Annals of Thoracic Surgery 2000 69, 1155-1161DOI: (10.1016/S0003-4975(99)01557-X)

Fig 5 Numerical density of capillaries and arterioles in the border zone of infarct, expressed as vessels per visual field. Treatment with basic fibroblast growth factor (bFGF) increased the number of capillaries and arterioles. The Annals of Thoracic Surgery 2000 69, 1155-1161DOI: (10.1016/S0003-4975(99)01557-X)