B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition. B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition.

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B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition. B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition. Six- to 7-week-old wild-type littermate control mice (WT; n = 5), Eμ-Myc mice treated with placebo (P) for 2 weeks (n = 5), and Eμ-Myc mice treated with everolimus (E) for 2 weeks (n = 7) were analyzed. A, average spleen weight (P vs. E, P = 0.001). B, percent B220+ splenocytes (P vs. E, P = 0.001). C, May Grunwald–Giemsa–stained cytospin preparations of unsorted splenocytes (top) and purified B220+ cells (bottom) in a representative mouse from each group. D, Fluorescence-activated cell sorting (FACS) plots showing surface expression of IgM and IgD in B220+-gated splenocytes for a representative mouse from each group. Error bars represent the SEM. P values were generated using a Student unpaired 2-tailed t test, *, P < 0.05. Meaghan Wall et al. Cancer Discovery 2013;3:82-95 ©2013 by American Association for Cancer Research

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