Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy Michael Kulis, PhD, Katie.

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Corinne A. Keet, MD, MS, Pamela A

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy Satya D. Narisety,

Sublingual immunotherapy for peanut allergy: A randomized, double-blind, placebo- controlled multicenter trial David M. Fleischer, MD, A. Wesley Burks,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Effects of time, albuterol, and budesonide on the shape of the flow-volume loop in children with asthma Anand C. Patel, MD, Mark L. Van Natta, MHS, James.

Chlamydophila (Chlamydia) pneumoniae serology and asthma in adults: A longitudinal analysis Rafael Pasternack, MD, PhD, Heini Huhtala, MSc, Jussi Karjalainen,

Tolerant beekeepers display venom-specific functional IgG4 antibodies in the absence of specific IgE Eva-Maria Varga, MD, Fahima Kausar, MSc, Werner.

Jay A. Lieberman, MD, Faith R. Huang, MD, Hugh A

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Is the prevalence of peanut allergy increasing

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD

Is 9 more than 2 also in allergic airway inflammation?

A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy Robert A.

Recombinant allergens: What does the future hold?

Clara cell 16-kd protein downregulates TH2 differentiation of human naive neonatal T cells Sofi Johansson, MSc, Göran Wennergren, MD, PhD, Nils Åberg,

Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis Carmen Rondón, MD, PhD, Paloma Campo,

Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis Chun Wei Li, PhD, Li Shi, MD, Ke Ke Zhang, MD, Tian.

A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response Pooja Varshney, MD, Stacie.

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy Justin M. Skripak, MD, Scott D. Nash, MD, Hannah.

Single–tree nut immunotherapy attenuates allergic reactions in mice with hypersensitivity to multiple tree nuts Mike Kulis, PhD, Yifan Li, BS, Hannah.

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy Satya D. Narisety,

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Serum tryptase levels in atopic and nonatopic children

A. Wesley Burks, MD, Robert A. Wood, MD, Stacie M. Jones, MD, Scott H

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Phillip Lieberman, MD, Michael Tankersley, MD

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

What are the best outcome measurements for atopic eczema

Allergen reference doses for precautionary labeling (VITAL 2

Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens Brian P. Vickery, MD, Jing Lin, PhD, Michael Kulis, PhD, Zhiyan Fu,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Allergen-specific immunotherapy with recombinant grass pollen allergens Marek Jutel, MD, Lothar Jaeger, MD, Roland Suck, PhD, Hanns Meyer, Dipl Math,

John A. Eckman, MD, Patricia M

What is an “eosinophilic phenotype” of asthma?

Allergenic significance of cephalosporin side chains

Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites Zhikang Peng, MD, Andrew N. Beckett, BSc,

Corinne A. Keet, MD, MS, Pamela A

Cockroach allergens: Coping with challenging complexity

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

House dust mite sublingual immunotherapy: Results of a US trial

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Brian P. Vickery, MD, Jelena P. Berglund, PhD, Caitlin M

Prevention of food allergy: Beyond peanut

Sublingual versus oral immunotherapy for peanut-allergic children: A retrospective comparison Stacy J. Chin, MD, Brian P. Vickery, MD, Michael D. Kulis,

Reply Journal of Allergy and Clinical Immunology

Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy Brian P. Vickery, MD, Amy M. Scurlock, MD, Michael Kulis,

Reply Journal of Allergy and Clinical Immunology

Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy Stacie M. Jones, MD, A.

Consumer attitudes and risks associated with packaged foods having advisory labeling regarding the presence of peanuts Susan L. Hefle, PhD, Terence J.

Macrolide antibiotics and asthma treatment

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

Asthma: The past, future, environment, and costs

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Personal and parental nativity as risk factors for food sensitization

Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis Andrea L. Jones, MD, Douglas Curran-Everett, PhD,

Effect of grass sublingual tablet immunotherapy is similar in children and adults: A Bayesian approach to design pediatric sublingual immunotherapy trials

Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization Edwin H. Kim, MD, J. Andrew Bird, MD, Michael Kulis,

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Double-blind, placebo-controlled study with a modified therapeutic vaccine of Salsola kali (Russian thistle) administered through use of a cluster schedule

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy Michael Kulis, PhD, Katie Saba, BS, Edwin H. Kim, MD, J. Andrew Bird, MD, Nikolas Kamilaris, BS, Brian P. Vickery, MD, Herman Staats, PhD, A. Wesley Burks, MD Journal of Allergy and Clinical Immunology Volume 129, Issue 4, Pages 1159-1162 (April 2012) DOI: 10.1016/j.jaci.2011.11.045 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Peanut-specific IgA levels in saliva and serum. A, C, and E show individual data, with a line indicating the median for salivary peanut-specific IgA, salivary peanut-specific S-IgA, and serum peanut-specific IgA levels, respectively. B, D, and F show changes for subjects from 0 to 12 months for salivary peanut-specific IgA, salivary peanut-specific S-IgA, and serum peanut-specific IgA levels, respectively. Matched pairs were compared by using the Wilcoxon signed-rank test. SLIT and placebo were compared with the Mann-Whitney test. Journal of Allergy and Clinical Immunology 2012 129, 1159-1162DOI: (10.1016/j.jaci.2011.11.045) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Correlations of DBPCFC or baseline peanut-specific IgE levels with changes in peanut-specific IgA levels. A-C, Salivary peanut-specific IgA (Fig 2, A), salivary peanut-specific S-IgA (Fig 2, B), and serum peanut-specific IgA (Fig 2, C) levels plotted with milligrams of peanut protein consumed during DBPCFC. Linear regression analysis was used to determine whether best-fit line slopes were significantly nonzero. D, Scatter plot of baseline peanut-specific IgE levels and change in salivary peanut-specific IgA levels. Blue circles represent subjects undergoing SLIT, and red diamonds represent placebo-treated subjects. Journal of Allergy and Clinical Immunology 2012 129, 1159-1162DOI: (10.1016/j.jaci.2011.11.045) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions