by Mawadda Alnaeeli, and Yen-Tung A. Teng

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by Mawadda Alnaeeli, and Yen-Tung A. Teng Dendritic cells differentiate into osteoclasts in bone marrow microenvironment in vivo by Mawadda Alnaeeli, and Yen-Tung A. Teng Blood Volume 113(1):264-265 January 1, 2009 ©2009 by American Society of Hematology

Immature but not mature CD11c+ DCs carry the osteoclastogenic potential. Immature but not mature CD11c+ DCs carry the osteoclastogenic potential. Freshly purified CD11c+ DCs (immature) or bacteria Aggregatibactor actinomycetemcomitans (Aa)–treated DCs for 24 or 48 hours (mature) were cultured with 30 to 100 ng/mL soluble receptor activator nb NFKB ligand (sRANKL) in the presence of 10 μg/mL Aa sonicated Ag (see Alnaeeli4). On day 5, the total number of TRAP+ multinucleated DC-derived OCs developed per unit area were quantified, using the protocol reported previously4 where the results are shown as mean plus or minus SE with *P = .001 (N = 5 experiments), and DC-only and DC + Aa as negative controls and Splenocytes + ConA as positive control. Mawadda Alnaeeli, and Yen-Tung A. Teng Blood 2009;113:264-265 ©2009 by American Society of Hematology