Absorption, Distribution, Metabolism and Elimination: Part I

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Presentation transcript:

Absorption, Distribution, Metabolism and Elimination: Part I Joseph Graziano, Ph.D.

Major Routes of Drug Administration Route of Administration Intramuscular: Intravenous: Absorption Pattern Prompt from aqueous solutions, but slow and sustained from repository forms Immediate effects, since absorption is circumvented

Major Routes of Drug Administration Route of Administration Oral Ingestion: Subcutaneous: Absorption Pattern Variable; depends on many factors Prompt from aqueous solutions, but slow and sustained from repository forms

Other Routes of Administration Transdermal patch Inhalation Intra-arterial Intrathecal Topical: ocular, dermal, intranasal, intravaginal routes all lead to some systemic absorption