NCOA5, IL-6, Type 2 Diabetes, and HCC: The Deadly Quartet

Slides:

Advertisements

Similar presentations

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Advertisements

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling Guobin He, Debanjan Dhar, Hayato Nakagawa, Joan.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development Hayato Nakagawa, Atsushi Umemura, Koji Taniguchi, Joan Font-Burgada,

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

Inflammation and Cancer: IL-6 and STAT3 Complete the Link

Volume 14, Issue 2, Pages (August 2011)

Ghrelin—a new player in glucose homeostasis?

The CD70-CD27 Axis, a New Brake in the T Helper 17 Cell Response

Making Muscle or Mitochondria by Selective Splicing of PGC-1α

Interleukins and Atherosclerosis: A Dysfunctional Family Grows

Amit Awasthi, Vijay K. Kuchroo Immunity

Novel SIRT1 Mutation Linked to Autoimmune Diabetes in Humans

Fat Chance: Not Much against NKT Cells

Does Hypothalamic Inflammation Cause Obesity?

In and Out: Adipose Tissue Lipid Turnover in Obesity and Dyslipidemia

Pancreatic β cells: Responding to the matrix

Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis

SCFAs Take a Toll En Route to Metabolic Syndrome

Volume 26, Issue 1, Pages 1-2 (July 2014)

Fingered for a Fat Fate Cell Metabolism

The Double Life of Irs Cell Metabolism

A Clock Ticks in Pancreatic β Cells

The Wind God Promotes Lung Cancer

Macrophage Metabolism Shapes Angiogenesis in Tumors

Gal3 Links Inflammation and Insulin Resistance

Come on BAIBA Light My Fire

Is Predisposition to NAFLD and Obesity Communicable?

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

Ning Li, Sergei I. Grivennikov, Michael Karin Cancer Cell

NCOA5, IL-6, Type 2 Diabetes, and HCC: The Deadly Quartet

Independent Control of Aging and Axon Regeneration

Life Is Short, if Sweet Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

Autophagy: A Sweet Process in Diabetes

Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki

Autophagy: A Potential Link between Obesity and Insulin Resistance

IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

IKKɛ: A Bridge between Obesity and Inflammation

Metformin and Insulin Meet in a Most Atypical Way

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

Is Growth Hormone Resistance/IGF-1 Reduction Good for You?

In and Out: Adipose Tissue Lipid Turnover in Obesity and Dyslipidemia

Silencing Insulin Resistance through SIRT1

Dietary Carbohydrates Impair Healthspan and Promote Mortality

Subhra K. Biswas, Raffaella Bonecchi Cell Metabolism

Do Cancer Cells Care If Their Host Is Hungry?

Exercise Controls Non-Coding RNAs

Volume 14, Issue 2, Pages (August 2011)

Adipose Dendritic Cells Come Out of Hiding

An IRKO in the Podo: Impaired Insulin Signaling in Podocytes and the Pathogenesis of Diabetic Nephropathy Susan B. Gurley, Thomas M. Coffman Cell Metabolism

Ann Marie Schmidt, Kathryn J. Moore Cell Metabolism

Treating Diabetes by Blocking a Vascular Growth Factor

Volume 1, Issue 1, Pages 9-14 (January 2005)

Role reversal: Brain insulin and liver STAT3

Macrophage Metabolism Shapes Angiogenesis in Tumors

Of Mice and Men: Not ExAKTly the Same?

IL-1β Activation as a Response to Metabolic Disturbances

AMPK and p53 help cells through lean times

Estrogens and Obesity: Is It All in Our Heads?

NF-κB, Inflammation, and Metabolic Disease

Presentation transcript:

NCOA5, IL-6, Type 2 Diabetes, and HCC: The Deadly Quartet Debanjan Dhar, Ekihiro Seki, Michael Karin Cell Metabolism Volume 19, Issue 1, Pages 6-7 (January 2014) DOI: 10.1016/j.cmet.2013.12.010 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 NCOA5 Haploinsufficiency Promotes Hepatic Inflammation, Insulin Resistance, and HCC Development Reduced NCOA5 expression induces insulin resistance by interfering with insulin signaling in the liver as well as by interfering with insulin production by pancreatic β cells. NCOA5 haploinsufficiency creates a protumorigenic microenvironment in the liver that results in HCC development, which partly depends on IL-6 overexpression by Kupffer cells. NCOA5 is also involved in ERα-mediated suppression of IL-6. Cell Metabolism 2014 19, 6-7DOI: (10.1016/j.cmet.2013.12.010) Copyright © 2014 Elsevier Inc. Terms and Conditions