Novel insights in the interplay between inflammation and metabolic diseases: A role for the pathogen sensing kinase PKR  Nicolas Marsollier, Pascal Ferré, Fabienne Foufelle  Journal of Hepatology  Volume 54, Issue 6, Pages 1307-1309 (June 2011) DOI: 10.1016/j.jhep.2010.11.037 Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Interplay between inflammation, stress, and metabolic pathways. Double-stranded RNA-dependent protein kinase (PKR) is a protein involved in the crosstalk between inflammation, stress response, and metabolic disorders. PKR is activated by lipids and cytokines and interferes with insulin signaling by a direct inhibitory phosphorylation of IRS-1 or by an indirect mechanism involving activation of c-Jun kinase. Journal of Hepatology 2011 54, 1307-1309DOI: (10.1016/j.jhep.2010.11.037) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions