Bone remodeling Lining cells Bone marrow.

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Presentation transcript:

Bone remodeling Lining cells Bone marrow

Origination TNF 1,25 D PTH IGF IL 6 Lining cells Bone marrow

Activation Pre-osteoclasts Rank Rank ligand Bone marrow

Activation Osteoclasts Bone marrow

Resorption Osteoclasts Bone marrow

Resorption Osteoclast apoptosis Bone marrow

Formation Osteoblasts Bone marrow

Formation Osteoid Bone marrow

Formation Osteoid Newly mineralized bone Bone marrow

Formation Osteoid Newly mineralized bone Bone marrow

Mineralization Newly mineralized bone Bone marrow

Mineralization Bone marrow

One Basic Multicellular Unit

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