Myriam Martin, PhD, Anders Gottsäter, MD, PhD, Peter M

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Complement activation and plasma levels of C4b-binding protein in critical limb ischemia patients Myriam Martin, PhD, Anders Gottsäter, MD, PhD, Peter M. Nilsson, MD, PhD, Tom E. Mollnes, MD, PhD, Bengt Lindblad, MD, PhD, Anna M. Blom, PhD Journal of Vascular Surgery Volume 50, Issue 1, Pages 100-106 (July 2009) DOI: 10.1016/j.jvs.2008.12.033 Copyright © 2009 Society for Vascular Surgery Terms and Conditions

Fig 1 Systemic complement activation and elevated C4BP plasma levels in critical limb (CLI) ischemia patients. A shows complement activation, determined by presence of circulating terminal complement complexes (TCCs), in CLI patients (1.17 ± 0.06/1.13 [0.73-1.45] AU/mL; n = 70) in comparison to healthy controls (0.69 ± 0.07/0.59 [0.37-0.88] AU/m; n = 47) and in patients with (1.33 ± 0.11/1.28 [1.07-1.70] AU/mL; n = 24) and without gangrene (1.1 ± 0.08/1.0 [0.72-1.37] AU/mL; n = 48). B illustrates increased plasma levels of C4BPtot and C4BPβ in CLI patients (351 ± 8.1/322 [255-412] μg/mL for C4BPtot; 314 ± 7.0/287 [222-366] μg/mL for C4BPβ; n = 194) compared with healthy controls (297 ± 8.0/288 [247-329] μg/mL for C4BPtot; 265 ± 7.0/263 [227-294] μg/mL for C4BPβ; n = 196). C demonstrates C4BPtot and C4BPβ plasma levels in CLI patients with (421 ± 28.6/386 [296-469] μg/mL for C4BPtot; 374 ± 25.4/332 [255-458] μg/mL for C4BPβ; n = 24) and without gangrene (341 ± 10.8/318 [244-403] μg/mL for C4BPtot; 305 ± 9.5/285 [220-363] μg/mL for C4BPβ; n = 170). *Denotes significant P value, evaluated using Mann-Whitney U-test, the horizontal line for each data set represents the median. Journal of Vascular Surgery 2009 50, 100-106DOI: (10.1016/j.jvs.2008.12.033) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

Fig 2 Correlation between C4BP and plasma levels of inflammatory mediators. A illustrates the correlation of IL-6, B of TNF-α and C of hs-CRP plasma levels with C4BPtot and C4BPβ plasma levels in CLI patients. D demonstrates the correlation between leukocyte count and C4BPtot as well as C4BPβ plasma levels. *Denotes significant P value, r = Spearman's rank correlation coefficient. Journal of Vascular Surgery 2009 50, 100-106DOI: (10.1016/j.jvs.2008.12.033) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

Fig 3 Correlation between C4BP and lipid plasma levels. A illustrates the correlation of triglyceride levels, B the correlation with LDL/HDL ratio and C the correlation of HDL levels with C4BPtot and C4BPβ plasma levels in CLI patients. *Denotes significant P value, r = Spearman's rank correlation coefficient. Journal of Vascular Surgery 2009 50, 100-106DOI: (10.1016/j.jvs.2008.12.033) Copyright © 2009 Society for Vascular Surgery Terms and Conditions