Agenda 7:30pm Welcome M. Everitt/R. Chinnock/J. Alejos 7:40pm Steering Committee Update Melanie Everitt 7:45pm DCC Update James Kirklin 8:00pm Database Committee Report Marc Richmond 8:15pm Foundation Update Craig Collum 8:30pm DISCUSSION Research Project Timeline of Submission Progression of Elections 8:55pm Pedimacs Update Betsy Blume 9:10pm Scientific Committee Report Anne Dipchand 9:20pm New Officers and New Business 9:30pm Adjourn

2017 Scientific Committee Members Anne Dipchand, MD (2018) Chair Elfi Pahl, MD (2018) Vice Chair/Secretary & Scientific-Steering Committee Liaison Members At Large Simon Urschel, MD (2017) Dan Bernstein, MD (2017) Charlie Canter, MD (2017) Matthew Fenton, MD (2017) Janet Scheel, MD (2017) Rocky Singh, MD, MS (2017) Scott Auerbach, MD (2018) Jennifer Conway, MD (2018) Ashwin Lal, MD (2018) Jacque Lamour, MD (2018) Bob Shaddy, MD (2018) Steve Webber, MD (2018) James Kirklin, MD Elizabeth Pruitt, MSPH

Submitted Manuscripts Status: November 2017 Topic PI/SRI Journal VAD (AHA 2012) Dipchand Kirklin JACC PTLD (ISHLT 2014) West Feingold JHLT LDS: Surveillance Biopsies (ISHLT 2016) Zinn Canter Pediatric Transplantation AE VAD (ISHLT 2017) Sutcliffe Blume

Manuscripts in Preparation Status: November 2017 Topic PI/SRI Status MCSD Graft Failure (ISHLT 2016) Simmonds Addonizio Dr. Simmonds to finalize manuscript with UAB Single Ventricle in MCSD Das Kirklin Dr. Das to finalize manuscript with UAB Diabetes Post-Transplant (AHA 2016) Sparks Morrow Dr. Sparks to finalize manuscript with UAB

Manuscripts in Preparation Status: November 2017 Topic PI/SRI Status <10 kg (ISHLT 2017) Conway Pahl Dr. Conway to finalize manuscript with UAB Fontan Dykes Almond Dr. Dykes to finalize manuscript Berlin Heart Jeewa Fraser Dr. Jeewa to finalize manuscript with UAB LDS: HLA Albers Law Dr. Albers to finalize manuscript Pulmonary Atresia (AHA 2017) Joong Gajarski Dr. Joong to finalize manuscript with UAB Hemodynamic Surveillance Arbon Kindel Dr. Arbon to finalize manuscript with UAB

Abstracts Submitted to ISHLT 2018 Topic PI/SRI Status Heterotaxy Khan Everitt Abstract submitted Renal Dysfunction (Pedimacs Linkage) Hollander Conway VAD Infection Auerbach Kirklin LDS: HC Rejection Kleinmahon Practice Variation Group: Surveillance Biopsy Godown Hsu Practice Variation Group: Surveillance Angiography Pahl Chin

Publications: May 2017 – November 2017

Recent Publications American Journal of Transplantation, Volume 17, Issue 6, June 2017, Pages 1525–1539

Recent Publications The Journal of Heart and Lung Transplantation  Volume 36, Issue 9, September 2017, Pages 996–1003

Recent Publications European Heart Journal, Volume 38, Issue 38, October 2017, pages 2900 - 2909

Recent Publications: In Press The Journal of Heart and Lung Transplantation, Accepted May 2017. In Press

Recent Publications: In Press Pediatric Transplantation, Accepted October 2017, In Press The Impact of Flow PRA on Outcome in Pediatric Heart Recipients in Modern Era: An Analysis of the Pediatric Heart Transplant Study Database Das B. B., MD,a Pruitt E., MSPH,b Molina K., MD,c Ravekes W., MD,d Auerbach S., MD,e Savage A., MD,f Knox L., RN, BSN, CCTC,g Kirklin J. K., MD,b Naftel D.C., PhD,b Hsu D., MD;h on behalf of the Pediatric Heart Transplant Study Investigators Abstract Data from patients in the Pediatric Heart Transplant Study (PHTS) registry transplanted between 2010 and 2014 were analyzed to determine the association between HLA antibody (PRA) determined by solid phase assay (SPA) using Luminex or flow cytometry with a positive retrospective crossmatch and the post-transplant outcomes of acute rejection and graft survival. A total of 1459/1596 (91%) recipients had a PRA reported pre-transplant; 26% had a PRA >20%. Patients with a PRA>20% were more likely to have congenital heart disease, prior cardiac surgery, extracorporeal membrane oxygenation support at listing, and waited longer for transplantation than patients with a PRA <20%. Patients with higher PRA% determined by SPA were predictive of a positive retrospective crossmatch determined by flow cytometric method (p<0.001). A PRA >50% determined by SPA was independently associated with worse overall graft survival after first month of transplant in both unadjusted and adjusted for all other risk factors. In this large multicenter series of pediatric heart transplant recipients, an elevated PRA determined by SPA remains a significant risk factor in the modern era.

Presentations at AHA

Amy C. Rothkopf3, James K. Kirklin2, and Robert J. Gajarski7 AHA 2017 Rapid-Fire Oral Presentation Monday, November 13, 10:10am – 11:20am Clinical III Forum, Science and Technology Hall Outcomes of Infants with Pulmonary Atresia with Intact Ventricular Septum Listed for Cardiac Transplantation: A Multi-Institutional Study Anna Joong1, Elizabeth Pruitt2, Warren A. Zuckerman3, James W. Blackston2, Rebecca K. Ameduri4, Juan C. Alejos5, Gerard J. Boyle6, Amy C. Rothkopf3, James K. Kirklin2, and Robert J. Gajarski7 1Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL; 2University of Alabama at Birmingham, Birmingham, AL; 3Columbia University-Morgan Stanley Children's Hospital of New York Presbyterian, New York, NY; 4University of Minnesota Masonic Children's Hospital, Minneapolis, MN; 5Mattel Children’s Hospital, Los Angeles, CA; 6Cleveland Clinic Foundation, Cleveland, OH; 7Naionwide Children's Hospital, Columbus, OH.

AHA 2017 Poster Presentation Tuesday, November 14, 1:30pm – 2:45p Clinical Section, Science and Technology Hall Are Routine Surveillance Invasive Hemodynamics Obtained Post-Transplant Useful in Pediatric Heart Transplant Recipients? Kate S. Arbon1, Yuk M. Law1, James K. Kirklin2, Elizabeth Pruitt2, Kenneth O. Schowengerdt3, Timothy M. Hoffman4, Thomas J. L’Ecuyer5, and Steven J. Kindel6 1Seattle Children’s Hospital, Seattle, WA; 2University of Alabama at Birmingham, Birmingham, AL; 3Cardinal Glennon Children's Medical Center, St. Louis, MO; 4University of North Carolina, Chapel Hill, NC; 5University of Virginia Medical Center, Charlottesville, VA; 6Children's Hospital of Wisconsin, Milwaukee, WI

Annual Fall Meeting, November 12, 2017 PHTS Working Groups Group 1: Immunosuppression Protocols Marc Richmond, MD, MS Group 2: Diagnoses of cellular rejection and surveillance  Daphne Hsu, MD Group 3: Diagnosis and treatment of CAV Elfi Pahl, MD

Practice Variation Workgroups Group 1: Immunosuppression Protocols Proposing revision of Initial Immunosuppression data collection form (Form 3) Examined era effect of medications

Practice Variation Workgroups Group 2: Diagnosis of Cellular Rejection and Surveillance Abstract submitted to ISHLT 2018 Examined center variability within first year and after first year of transplant Surveillance practices Diagnosis practices Recipient age related practices Preparing manuscript

Practice Variation Workgroups Group 3: Diagnosis and Treatment of CAV Abstract submitted to ISHLT 2018 Examined center variability for coronary evaluation methods Surveyed centers about angiography frequency Preparing protocol guidelines