Inflammation/Immune Issues

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Presentation transcript:

Inflammation/Immune Issues

New β-Cell Centric Construct: Implications Inflammation/ Immune Dysregulation Issues-ALL DM Same Processes for T1DM, T2DM - Same AND Different Triggers T1DM T2DM Yumi Imai1, Anca D. Dobrian2, Margaret A. Morris1,3, and Jerry L. Nadler,Islet inflammation: a unifying target for diabetes treatment? Trends in Endocrinology and Metabolism 2013:1-10 ; Barbara Brooks-Worrell, Radhika Narla, and Jerry P. Palmer Biomarkers and immune-modulating therapies for Type 2 diabetes Trends in Immunology November 2012, Vol. 33, No. 11; James JohnsonUniversity of British Columbia Vancouver, BC, Canada

Obesity Increases Anti-Islet Cell Adipo-cytokines/ Inflammation Beta Cell apoptosis Apoptosis Beta Cell Haptoglobin Gene Variant Associated with leaky gut Gut Microbiota Trigger Inflammation/ Immune destruction of B-Cell in ‘T1DM’

Pathogenesis and biological interventions in T1DM- LIKE autoimmune diabetes- Insulitis The class I MHC molecules are hyperexpressed on the β-cell surface in T1D patients making β-cells more susceptible to cytotoxic lymphocyte (CTL)-mediated destruction. Novel diagnostic and therapeutic approaches for autoimmune diabetes — A prime time to treat insulitis as a disease http://dx.doi.org/10.1016/j.clim.2014.11.007 Clinical Immunology, 2014 Juha Grönholm , Michael J. Lenardo

Efficacy of Immunotherapy in T1DM: Some Can Delay Decline in C-peptide Woittiez, Roep, Immunotherapy (2015) 7(2), 163–174