Didier Trono, Flavia Marzetta Cell Host & Microbe

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Presentation transcript:

Profaning the Ultimate Sanctuary: HIV Latency in Hematopoietic Stem Cells Didier Trono, Flavia Marzetta Cell Host & Microbe Volume 9, Issue 3, Pages 170-172 (March 2011) DOI: 10.1016/j.chom.2011.03.001 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 A Two-Step Reservoir? Initial transmission and early spread of HIV infection are mediated primarily by R5-tropic viruses. Infection of CD4+ T lymphocytes results in the establishment of a reservoir of latently infected resting cells that can be maintained by homeostatic proliferation and cell activation. At later stages, X4-tropic HIV isolates eventually emerge, and this switch of dominance from R5-tropic to X4-tropic HIV correlates with rapid disease progression. CXCR4-tropic viruses can infect multipotent HSCs, which might represent a truly permanent source of virus in infected individuals. Cell Host & Microbe 2011 9, 170-172DOI: (10.1016/j.chom.2011.03.001) Copyright © 2011 Elsevier Inc. Terms and Conditions