Moderate-Intensity Statins for Dyslipidemia: How to Treat Today?

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Presentation transcript:

Moderate-Intensity Statins for Dyslipidemia: How to Treat Today?

2013 ACC/AHA Cholesterol Guidelines Statin Initiation Recommendations

Multiple Challenges in Statin Selection

Intensity of Statin Therapy

2013 ACC/AHA Cholesterol Guidelines Statin Safety Recommendations

Unified Definition of Statin Intolerance

Selected Drug Interactions That Increase Statin Levels

Before Initiating Statin Therapy

Statins and Risk for New-Onset T2D

T2D Risk Increases With Statin Potency Meta-Analysis of 5 Clinical Trials

Risk of T2D Lower With Some Statins

Polypharmacy and Drug-Drug Interactions

Interprofessional Team Approach Improving Statin Therapy

REAL-CAD

REAL-CAD: Primary Endpoint CV Death/MI/Ischemic Stroke/UA

REAL-CAD: Secondary Composite Endpoint

REAL-CAD Safety Outcomes

Case: Statin-Naive Patient With CAD Patient Background

Case (cont) Laboratory Findings

Case (cont) Initial Treatment

Case (cont) Patient Discontinued Atorvastatin Due to AE

Case (cont) Switching to Rosuvastatin

Case (cont) Switching to Pitavastatin

Clinical Pearls From Case

Management of Statin-Related AEs

Spectrum of Statin-Associated Muscle AEs

Risk Factors for Statin-Associated Muscle AEs

Reasons for Increased ASCVD Risk in HIV Infection

Use of Statins With PIs

2013 ACC/AHA Cholesterol Guidelines Initiating Statin Therapy in Individuals With Clinical ASCVD

Greater LDL-C Reduction With High- vs Low-Intensity Statin

IMPROVE-IT: Benefit With Ezetimibe

Take Home Messages

Abbreviations

Abbreviations (cont)

Abbreviations (cont)