Data Acquisition for Sleep Architecture Study Andrew Myers Ross Fuller Advisor: Dr. John Cohen

Objectives Sleep Study Data Acquisition Conversion of pH data EEG, EMG, EOG, EKG, pH, Respiratory Rate, Oxygen Saturation Conversion of pH data Conversion from hexadecimal to decimal Event recognition (pH < 4) Import data into database

The Sleep Study The effects of fundoplication on subjects experiencing sleep disruption due to nocturnal gastroesophageal reflux disorder (GERD) Conducted in a clinical setting at the Vanderbilt Medical Center’s General Clinical Research Center

GERD is a common disorder... 40% of Americans suffer monthly. 7% of Americans suffer daily. 25% of Americans take an antacid >2x/month It is the most common acid-related disorder. It is becoming more common as the population ages.

What is not known? The exact relationship between reflux events and sleep stage in normal volunteers and GERD patients. How fundoplication affects objective sleep patterns in patients with GERD.

Fundoplication

GCRC Utilization 2 Nights per Subject 21 Subjects Single Occupancy in a Double Room Meals, Medications Sleep tech responsibilities if CRC desires

Procedure Admit to CRC Perform pregnancy test Perform Esophageal manometry & place pH probe at GERD Center ~10pm Set up EEG Equipment After 8hrs of sleep, remove EEG Equipment Remove pH probe

Analysis Esophageal pH data downloaded Sleep data interpreted by neurologist (blinded) Questionnaire, pH, sleep data integrated on database

Work Completed (1) "05 01C3 Samples" "3F433D413F413D413D423D4340413D413E453F443F413E453F463E433D413D433D413E423D413E463D423E413C443D” Visual Basic code converting this to decimal Output file displays events (pH<4) at the time of occurrence Synchronized with EEG machine providing sleep comparison

Work Completed (2) Successful practice run on overnight patient Proper EEG, EMG, EOG, EKG sensitivity and filter settings Neurologist can determine stage with 5 second accuracy Event recognition of pH code

Future Work Designsafe Analysis Start actual study (first patient last Friday) Determine if collected data is adequate as deemed by the advisor (Dr. John Cohen) and the neurologist Direct import of data into the database