Deoxyribonucleotide production

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Presentation transcript:

Deoxyribonucleotide production Title slide.

A) Model of the enzyme; b) a ribbon diagram of R2 Fe III is orange, tyr 122 has green Cs and red Os, c) the binuclear Fe III, and d) a ribbon diagram of the R1 subunit.

Another representation of the ribonucleotide reductase model.

The reaction sequence.

The overall reaction is the reduction of 2’ OH.

The reactions of the -SHs.

E. coli thioredoxin.

Ribbon diagram of a 320-residue subunit of the homodimeric E Ribbon diagram of a 320-residue subunit of the homodimeric E. coli thioredoxin reductase.

Glutathione, glutathione reductase.

Thioredoxin reductase involvement.

Another representation.

The control network for controlling ribonucleotide reductase.

The reponse to high [ATP].

Thymidylate synthase and inhibitory sites.