The prevalence of abdominal aortic aneurysm is consistently high among patients with coronary artery disease Jussi A. Hernesniemi, MD, PhD, Ville Vänni,

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The prevalence of abdominal aortic aneurysm is consistently high among patients with coronary artery disease Jussi A. Hernesniemi, MD, PhD, Ville Vänni, MD, Tapio Hakala, MD, PhD Journal of Vascular Surgery Volume 62, Issue 1, Pages 232-240.e3 (July 2015) DOI: 10.1016/j.jvs.2015.02.037 Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 1 Flow chart demonstrating those studies that were processed for inclusion in the meta-analysis. AAA, Abdominal aortic aneurysm; CABG, coronary artery bypass grafting; CAD, coronary artery disease. Journal of Vascular Surgery 2015 62, 232-240.e3DOI: (10.1016/j.jvs.2015.02.037) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 2 Meta-analysis of the risk of abdominal aortic aneurysm (AAA) related to history of coronary artery disease (CAD) in cohort studies screening for AAA in the general population. Significant heterogeneity was observed (I2 = 97.8%; P < .001 for heterogeneity), and therefore a random-effects model was applied. P = 4.1 × 10−9 for t he risk estimate. CI, Confidence interval; OR, odds ratio. Journal of Vascular Surgery 2015 62, 232-240.e3DOI: (10.1016/j.jvs.2015.02.037) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 3 Funnel plot of the included studies depicting the association between abdominal aortic aneurysm (AAA) and coronary heart disease (CHD). P = .057 for plot funnel asymmetry by the Egger test and P = .712 by the test of Thompson and Sharp, which was applied because of high heterogeneity between studies (based on a weighted linear regression of the treatment effect on its standard error using the method of moments estimator for the additive between-study variance component). The expected fixed mean effect is skewed to the right because of the high estimate in the largest study by Kent et al. Journal of Vascular Surgery 2015 62, 232-240.e3DOI: (10.1016/j.jvs.2015.02.037) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 4 Meta-analysis of the risk of an abdominal aortic aneurysm (AAA) event during follow-up related to underlying coronary artery disease (CAD) at baseline. An AAA event was defined as a fatal or nonfatal AAA event (12% fatal). Most of the cases (85%) in all four studies combined were hospitalizations due to symptomatic AAA (also including emergency operations). In the smallest included study (by Lee et al), most cases (34/40) were asymptomatic AAAs discovered on ultrasound screening after a 5-year follow-up. CI, Confidence interval; HR, hazard ratio. Journal of Vascular Surgery 2015 62, 232-240.e3DOI: (10.1016/j.jvs.2015.02.037) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig 5 The prevalence of abdominal aortic aneurysm (AAA) among patients with angiographically verified coronary artery disease (CAD) or undergoing coronary artery bypass grafting (CABG). CI, Confidence interval. Journal of Vascular Surgery 2015 62, 232-240.e3DOI: (10.1016/j.jvs.2015.02.037) Copyright © 2015 Society for Vascular Surgery Terms and Conditions