Volume 145, Issue 1, Pages 253-254 (July 2013) Low Hepatocyte Repopulation From Stem Cells: A Matter of Hepatobiliary Linkage Not Massive Production  Neil D. Theise  Gastroenterology  Volume 145, Issue 1, Pages 253-254 (July 2013) DOI: 10.1053/j.gastro.2013.02.052 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 A, Label (BrdrU) retaining peribiliary hepatocytes (black nuclei) in murine acute acetaminophen toxicity represent the majority of label retaining cells in this injury model and probably derive from the smallest cholangiocytes of the canals of Hering (CoH; DAB stained pan-keratin, brown) to which they are connected (stain: hematoxylin counterstain; original magnification: ×40). B, Laminin staining in human liver is continuous around all ducts and ductules, but is interupted at the CoH:hepatocyte interface (arrow), a distinctive discontinuity that may relate to a specialized repopulating function of the CoH as a stem cell niche and be responsible for the unique ductular reactions that are seen in liver, but no other organ (DAB;stain: hematoxylin counterstain; original magnification: ×40). C, Laminin staining of human pancreas shows continuous basement membrane around all duct, acinar, and islet structures (*; DAB; stain: hematoxylin counterstain; original magnification: ×20). D, Laminin staining of human colon shows continuous basement membrane around all intestinal crypts (DAB; stain: hematoxylin counterstain; original magnification: ×10). (Laminin staining images provided by Christine Sempoux, Université Catholique de Louvain, Belgium.) Gastroenterology 2013 145, 253-254DOI: (10.1053/j.gastro.2013.02.052) Copyright © 2013 AGA Institute Terms and Conditions