Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL by Susan L. Slager, Kari G. Rabe, Sara J. Achenbach, Celine M. Vachon, Lynn R. Goldin, Sara S. Strom, Mark C. Lanasa, Logan G. Spector, Laura Z. Rassenti, Jose F. Leis, Nicola J. Camp, Martha Glenn, Neil E. Kay, Julie M. Cunningham, Curtis A. Hanson, Gerald E. Marti, J. Brice Weinberg, Vicki A. Morrison, Brian K. Link, Timothy G. Call, Neil E. Caporaso, and James R. Cerhan Blood Volume 117(6):1911-1916 February 10, 2011 ©2011 by American Society of Hematology

Trend test P values (as −log10 values; left y axis) are shown for SNPs analyzed in GWA study. Trend test P values (as −log10values; leftyaxis) are shown for SNPs analyzed in GWA study. Recombination rate is shown across the region with the solid line (right y axis). Triangles indicate imputed SNPs and circles indicate observed SNPs. Coloring (black, light gray, white) shows the extent of LD between each SNP and rs391525. Black: r2 ≥ 0.75; light gray: 0.25 ≤ r2 < 0.75; white: r2 < 0.25. (A) Association results of the 16q24 locus across a 60-kb region between all discovery CLL cases and controls. (B) Association results of the 6q21.3 locus between the discovery familial CLL cases and controls. Susan L. Slager et al. Blood 2011;117:1911-1916 ©2011 by American Society of Hematology