Med Chem Tutoring for Narcotics By Alaina Darby Adarby1@uthsc.edu

Which of the following is a sleep inducing agent that has addictive and abuse potential? Opioid Narcotic Endorphin analgesic B

Which of the following is a drug that blocks nociception without causing sedation? Opioid Narcotic Endorphin analgesic D

Which of the following is a substance with morphine-like pharmacological effects? Opioid Narcotic Endorphin analgesic A

Which of the following refers to all endogenous opioid receptor ligands? Narcotic Endorphin analgesic C

Which of the following is true? High agonist potency will have high analgesic potency High agonist potency will have low analgesic potency low agonist potency will have high analgesic potency agonist potency does not translate to analgesic potency D

Which of the following is the required sequence for endorphins? Arg-arg-gln-phe Tyr-gly-gly-phe Tyr-gly-gly-leu Tyr-GLn-gln-phe B

Which of the following is not one of the main opioid receptors? Mu Gamma Kappa delta B

Which of the following is an action of the mu receptor when agonized? Dysphoria Diuresis Respiratory rate depression Emetic effects D

Activation of which of the following receptors can protect against addiction? Mu Kappa delta B

Which of the following ligands only binds to the kappa receptor? B-endorphins Dynorphins Enkephalins B

Which of the following would increase activity Which of the following would increase activity? (structure is provided as reference for ring numbering) 3-H to 3-OH 3-OH to 3-CH3o 3-acetyl N-ch2ch2phenyl to n-ch3 A

Which of the following would decrease activity Which of the following would decrease activity? (structure is provided as reference for ring numbering) 6-oh to h 7,8-dihydro 14-b-oh 6-oh to keto D

Which of the following would cause the structure to be an antagonist Which of the following would cause the structure to be an antagonist? (structure is provided as reference for ring numbering) N-ch3 to n-ch2ch=ch2 14-b-oh 6-acetyl 7,8-dihydro A

Which of the following would result in a 10x decrease in activity Which of the following would result in a 10x decrease in activity? (structure is provided as reference for ring numbering) 3-H to 3-oh N-ch2ch2phenyl to n-ch3 3-oh to 3-ch3o 6-h to 6-oh B

What is the correct order to 4,5-epoxymorphian analgesic activity? Codeine, hydrocodone, oxymorphone, oxycodone Hydrocodone, codeine, oxycodone, oxymorphone Codeine, hydrocodone, oxycodone, oxymorphone Codeine, oxymorphone, hydrocodone, oxycodone C

Which of the following is a mu partial agonist and delta and kappa antagonist? Buprenophine Nalbuphine Butophanol pentazocine A

Which of the following is not a pure antagonist? Naloxone Naltrexone Nalbuphine methylnaltrexone C

Which of the following is missing only the E ring? Morphinian analog Benzomorphans 4-anilidopiperidine Phenylalkylamines A

Which of the following contains only the a,b, and d rings? Morphinian analog Benzomorphans 4-anilidopiperidine Phenylalkylamines B

Which of the following retains only the a and d rings? Morphinian analog Benzomorphans 4-anilidopiperidine Phenylalkylamines C

Which of the following retains only the a ring? Morphinian analog Benzomorphans 4-anilidopiperidine Phenylalkylamines D

Which of the following is not used as an antidiarrheal? Diphenoxylate Difenoxin Meperidine loperamide C

Into which of the following is butorphanol classified? Morphinian analog Benzomorphans 4-anilidopiperidine Phenylalkylamines A

Into which of the following is tramadol classified? Morphinian analog Benzomorphans 4-anilidopiperidine Phenylalkylamines D

Into which of the following is fentanyl classified? Morphinian analog Benzomorphans 4-anilidopiperidine Phenylalkylamines C