12 A Cell Nucleus Chapter 12: Chromosome 12 144,475 149 aa ABCC9 DNA Sequence Chromosome 144,475 Name of Protein 12 Name of Gene ATP-binding cassette, sub-family C (CFTR/MRP), member 9 ABCC9 transcription Amino acid sequence mRNA 149 aa translation Cytoplasm A Cell Nucleus What does this protein make up or do? ABC proteins transport various molecules across extra- and intra-cellular membranes Condition/Disease Mutations in this gene are associated with cardiomyopathy

Description of Chromosome 12 Symptoms and characteristics . ABC proteins transport various molecules across extra- and intra- cellular membranes This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP- sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel- modulating subunit of the extra- pancreatic ATP-sensitive potassium channels.

Who is affected? Anyone, but the following have a higher risk: Anyone who has sleep deprivation in there family tree Outlook or quality of life There are many types of ways to deal or aid sleep deprivation. Sleeping medication. Researcher: DS

References http://www.genecards.org/cgi- bin/carddisp.pl?gene=ABCC9 http://www.ncbi.nlm.nih.gov/gene/1006 0 References